Category: Medical Research

Northwestern researchers have discovered that when the human egg is activated by a sperm enzyme, an explosion of zinc sparks erupt


Northwestern University researchers have discovered that when the human egg is activated by a sperm enzyme, an explosion of zinc sparks erupt

If the videos do not start automatically, then click on the two  links below. They are from the study published in Scientific Reports

http://www.nature.com/article-assets/npg/srep/2016/160426/srep24737/extref/srep24737-s1.avi

http://www.nature.com/article-assets/npg/srep/2016/160426/srep24737/extref/srep24737-s2.avi

Video is courtesy of GeoBeats News YouTube channel

Abstract

Egg activation refers to events required for transition of a gamete into an embryo, including establishment of the polyspermy block, completion of meiosis, entry into mitosis, selective recruitment and degradation of maternal mRNA, and pronuclear development. Here we show that zinc fluxes accompany human egg activation. We monitored calcium and zinc dynamics in individual human eggs using selective fluorophores following activation with calcium-ionomycin, ionomycin, or hPLCζ cRNA microinjection. These egg activation methods, as expected, induced rises in intracellular calcium levels and also triggered the coordinated release of zinc into the extracellular space in a prominent “zinc spark.” The ability of the gamete to mount a zinc spark response was meiotic-stage dependent. Moreover, chelation of intracellular zinc alone was sufficient to induce cell cycle resumption and transition of a meiotic cell into a mitotic one. Together, these results demonstrate critical functions for zinc dynamics and establish the zinc spark as an extracellular marker of early human development.

Click on this line to visit the Northwestern University website page where this research is discussed.

Click on this line to visit the Scientific Reports website to read the complete study titled:

The zinc spark is an inorganic signature of human egg activation

Please note that there is download link at the above linked to Scientific Reports site, which allows you to download the full study report.

Title:
The zinc spark is an inorganic signature of human egg activation

Authors: Francesca E. Duncan, Emily L. Que, Nan Zhang, Eve C. Feinberg, Thomas V. O’Halloran et al.

Publication: Scientific Reports

Publisher: Nature Publishing Group

Date: Apr 26, 2016

Copyright © 2016, Rights Managed by Nature Publishing Group

Creative Commons

The article for which you have requested permission has been distributed under a Creative Commons CC-BY license (please see the article itself for the license version number). You may reuse this material without obtaining permission from Nature Publishing Group, providing that the author and the original source of publication are fully acknowledged, as per the terms of the license.
For license terms, please see http://creativecommons.org/

 

Posted by: Vincent Banial
http://www.uniquelytoronto.com

Disclaimer: Any Trademarks mentioned in this post are owned by the respective Trademark owner.

If the Cancerous Tumor can be reached by thin optic fibers then this minimally invasive procedure could be an effective way to treat said Tumor

Getting any form of cancer can be life changing. The medical procedures used to eliminate the Cancer can also have life changing side effects.

Removing a Cancerous Prostate is one present way to deal with Colon Cancer.

There is a novel new procedure which has already been approved for use in Mexico. It may soon be approved for use in Europe.

The key part is that the procedure is minimally invasive. If the Cancerous Tumor can be reached by thin optic fibers then this procedure could be an effective way to treat said Tumor. The thin optic fiber is needed to direct the Laser light at the Tumor. “Laser light activation of an intravenous infusion of Tookad Soluble releases short-lived toxic oxygen and nitric oxide radicals that destroy the Cancer tumor’s blood vessels and thereby kill the tumorous cells”. The Tookad Soluble drug is eliminated from the body in less than 6 hours. Without the Laser Light activation the Tookad Soluble has no effect on other cells or organ. Ultra Sound is used to feed and direct the Optic Fibres into the patients body.

This new technology was developed by the Yeda Research and Development Company, of the Weizmann Institute in collaboration with Steba Biotech of Luxembourg. Steba Biotech received the license for Tookad Soluble from Yeda Research and Development Company.

Since this procedure can target Cancer Tumors where a Fibre Optic strand could reach the tumor, then the door may be open to treat many other forms of Cancer. More research and Clinical Studies are underway.

Click on this line to read much more detail about using Tookad Soluble activation via Laser Light to target Cancer Tumors.

Click on this line to visit the Times Of Israel news website to read their article on this procedure first developed by the Weizmann Institute.

 

 

Posted by: Vincent Banial
http://www.uniquelytoronto.com

Disclaimer: Any Trademarks mentioned in this post are owned by the respective Trademark owner. There could be unintentional errors or omissions in this post. Always refer to the official sites to confirm details and any ongoing changes or updates. This post is subject to change without notice.

Scanning ultrasound removes amyloid-β and restores memory in an Alzheimer’s disease mouse model

I used to post about Medical Research in the past. For example, our prior post about research done at Harvard regarding the association between Heart Disease and microbial Human Gut Bacteria had researchers from around the globe visiting this site. Hey life is not just about great looking Exotic Cars, great looking Women and great sounding Music. You should add Medical Research to “round out” that mix.

This post is about research being conducted in Australia, which shows great promise in the treatment of Alzheimers. Apparently some memory loss could be reversed, in mice so far, by using their protocol and Scanning UltraSound.

The study was conducted by : Gerhard Leinenga and Jürgen Götz. Corresponding author. E-mail: j.goetz@uq.edu.au

Their study was published in the peer reviewed journal: Science Translational Medicine 11 Mar 2015: Vol. 7, Issue 278

The article was titled: Research Article Alzheimer’s Disease
Scanning ultrasound removes amyloid-β and restores memory in an Alzheimer’s disease mouse model.

The following is the Abstract (posted for Educational purposes). A link is provided further down to access the complete text and a downloadable PDF.

Abstract

Amyloid-β (Aβ) peptide has been implicated in the pathogenesis of Alzheimer’s disease (AD). We present a nonpharmacological approach for removing Aβ and restoring memory function in a mouse model of AD in which Aβ is deposited in the brain. We used repeated scanning ultrasound (SUS) treatments of the mouse brain to remove Aβ, without the need for any additional therapeutic agent such as anti-Aβ antibody. Spinning disk confocal microscopy and high-resolution three-dimensional reconstruction revealed extensive internalization of Aβ into the lysosomes of activated microglia in mouse brains subjected to SUS, with no concomitant increase observed in the number of microglia. Plaque burden was reduced in SUS-treated AD mice compared to sham-treated animals, and cleared plaques were observed in 75% of SUS-treated mice. Treated AD mice also displayed improved performance on three memory tasks: the Y-maze, the novel object recognition test, and the active place avoidance task. Our findings suggest that repeated SUS is useful for removing Aβ in the mouse brain without causing overt damage, and should be explored further as a noninvasive method with therapeutic potential in AD.

Click on this line to view the complete text regarding the published results of this study.

Click on this line to view the entire article as a PDF or to Download a PDF copy of the Published material courtesy of the Science Translational Medicine site.

Click on this line to visit the official website of the Queensland Brain Institute at The University of Queensland Australia

Click on this line to visit the Clem Jones Centre for Ageing Dementia Research (CJCADR)

 

 

Posted by: Vincent Banial
http://www.uniquelytoronto.com

Disclaimer: Any Trademarks mentioned in this post are owned by the respective Trademark owner. There could be unintentional errors or omissions in this post. Always refer to the official sites to confirm details and any ongoing changes or updates. This post is subject to change without notice. The Study Abstract has been included in this post for Educational Purposes and so is covered by the Fair Use component of Copyright. Uniquely Toronto makes no claims regarding the copyright or other rights to the published material. Also complete links have been included to the Science Translational Medicine site.

The Truth About Cancer: A Global Quest docu-series – official trailer

Video is courtesy of The Truth About Cancer YouTube channel

 

 

Posted by: Vincent Banial
http://www.uniquelytoronto.com

Disclaimer: Any Trademarks mentioned in this post are owned by the respective Trademark owner.

Fasting may have postive effects on Human Brains. This Ted Talk is presented by Neuroscientist Mark Mattson

A very interesting Ted Talk about the positive effects of fasting on the Brain. It is presented by Mark Mattson is the current Chief of the Laboratory of Neurosciences at the National Institute on Aging.

Video is courtesy of the TEDx Talks YouTube channel

From the research which Mark Mattson is undertaking, Fasting could benefit those suffering with Alzheimer’s Disease & Dementia.

As the number of Alzheimer’s Disease & Dementia patients spiral upwards, the research on Fasting could prove most important.

Posted by: Vincent Banial
www.uniquelytoronto.com

Disclaimer: Any Trademarks mentioned in this post are owned by the respective Trademark owner.

New Contagious form of Cancer discovered

Click n the link below to read the article posted on the Business Standard website, about a new Contagious for of Cancer which has been discovered.

http://mybs.in/2S2uNPj

Cancer is “very rarely” contagious. I believe that there exist only about 2 or 3 forms of cancer, which can survive the move from the original Host body to the Next Host body.

Posted by: Vincent Banial
www.uniquelytoronto.com

Disclaimer: Any Trademarks mentioned in this post are owned by the respective Trademark owner. There could be unintentional errors or omissions in this post. Always refer to the official sites to confirm details and any ongoing changes or updates. This post is subject to change without notice. Posting links is covered under the Fair Use Provision of Copyright. Permission was also granted by the Business Standard site to share their post link.

New Medical Study just published in the journal Cell: Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis

TMAlyase_GUT_graphical abstract_HAZEN-3Image is courtesy of the journal Cell which retains the Copyright and any and all other rights. Used with permission for educational purpose.

A new study just published in the peer reviewed journal Cell goes further into the research which we had posted about on Apil 08 2013. That 2013 post was titled : Intestinal microbiota metabolism producing Trimethylamine-N-Oxide (TMAO), may be a contributing factor in developing Cardiovascular Disease in Humans. That was an extremely important study which had been published in the peer reviewed journal Nature Medicine. Click on the previous line to read about that extremely important finding, as I believe that it presents a new foundation upon which we can potentially reverse Cardiovascular Disease in Humans.

The following are quotes about the new study from the journal Cell which was titled:
Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis

Highlights

•Gut microbial trimethylamine lyases are a therapeutic target for atherosclerosis
•3,3-dimethyl-1-butanol inhibits microbial trimethylamine formation
•3,3-dimethyl-1-butanol attenuates choline diet-enhanced atherosclerosis
•Non-lethal gut microbial enzyme inhibition can impact host cardiometabolic phenotypes

Summary

Trimethylamine (TMA) N-oxide (TMAO), a gut-microbiota-dependent metabolite, both enhances atherosclerosis in animal models and is associated with cardiovascular risks in clinical studies. Here, we investigate the impact of targeted inhibition of the first step in TMAO generation, commensal microbial TMA production, on diet-induced atherosclerosis. A structural analog of choline, 3,3-dimethyl-1-butanol (DMB), is shown to non-lethally inhibit TMA formation from cultured microbes, to inhibit distinct microbial TMA lyases, and to both inhibit TMA production from physiologic polymicrobial cultures (e.g., intestinal contents, human feces) and reduce TMAO levels in mice fed a high-choline or L-carnitine diet. DMB inhibited choline diet-enhanced endogenous macrophage foam cell formation and atherosclerotic lesion development in apolipoprotein e−/− mice without alterations in circulating cholesterol levels. The present studies suggest that targeting gut microbial production of TMA specifically and non-lethal microbial inhibitors in general may serve as a potential therapeutic approach for the treatment of cardiometabolic diseases.”

The authors and researchers of this new Study were:
Zeneng Wang, Adam B. Roberts, Jennifer A. Buffa, Bruce S. Levison, Weifei Zhu, Elin Org, Xiaodong Gu, Ying Huang, Maryam Zamanian-Daryoush, Miranda K. Culley, Anthony J. DiDonato, Xiaoming Fu, Jennie E. Hazen, Daniel Krajcik, Joseph A. DiDonato, Aldons J. Lusis and Stanley L. Hazen

Click on this line to visit the journal Cell website, which features the Full Text of this important newly published Study.

Click on this line to download the PDF of this new Study, from the Journal Cell’s website.

In laymen’s terms, this new Study (published in the journal Cell, showed that by lnhibiting the production of TMAO during the digestion process, clogging of arteries was vastly reduced in Mice. What worked in Mice could work in a similar manner in Humans. This study, in my opinion, adds a new layer to the very important knowledge foundation which was laid with the initial work published in the journal Nature Medicine (click here to view that post)

 

 

Posted by: Vincent Banial
http://www.uniquelytoronto.com

Disclaimer: Any Trademarks mentioned in this post are owned by the respective Trademark owner. There could be unintentional errors or omissions in this post. Always refer to the official sites to confirm details and any ongoing changes or updates. This post is subject to change without notice. Neither Vincent Banial nor Uniquely Toronto make any claims to the copyright to the material discussed in the above post. Copyright is retained by the authors of the study and with the journal Cell.

This post is not meant to be medical advice. Always seek the help and advice of your on Medial Doctor. This post is strictly for “Educational Purposes”. Our initial post about TMAO (posted on April 08 2013 is one of our most popular posts. Students and researches from all around the globe have visited our site just to read that educational post.

Knowledge is power and I strive to give back to humanity, by posting information for educational purposes, such as this post.

This post is also licensed to share under the Creative Commons License

Attribution-NoDerivs
CC BY-ND

This license allows for redistribution, commercial and non-commercial, as long as it is passed along unchanged and in whole, with Credit and Attribution to Vincent Banial.

The University of Iowa medical study finds Diet Drink consumption may be associated with heart trouble for older women

I know, I know that I said that I won’t be posting here for a while. I’ll likely have withdrawal symptoms this weekend <grin>.

I just ran across the results from a large medical study which looked at Diet Drink consumption and cardiovascular health in almost 60,000 women. The University of Iowa medical study found Diet Drink consumption may be associated with heart trouble for older women and I felt that it was important enough to take some time and post a link to it.

Click on the following link to read more details from The University of Iowa :

http://now.uiowa.edu/2014/03/ui-study-finds-diet-drinks-associated-heart-trouble-older-women

Posted by: Vincent Banial for Uniquely Toronto
http://www.uniquelytoronto.com

Disclaimer: Any Trademarks mentioned in this post are owned by the respective Trademark owner. There could be unintentional errors or omissions in this post. Always refer to the official sites to confirm details and any ongoing changes or updates. This post is subject to change without notice.

An Aspirin a day could double survival chances of cancer sufferers

http://www.express.co.uk/life-style/health/608395/Cancer-survival-aspirin-a-day-pill-breast-heart-disease-Alzheimer-s-disease

Posted by: Vincent Banial for Uniquely Toronto
http://www.uniquelytoronto.com

Disclaimer: Any Trademarks mentioned in this post are owned by the respective Trademark owner. There could be unintentional errors or omissions in this post. Always refer to the official sites to confirm details and any ongoing changes or updates. This post is subject to change without notice.

Brain implant could reverse memory loss in Alzheimers patients

http://www.express.co.uk/news/uk/609875/new-implant-reverse-Alzheimers-memory-loss-high-tech-device-treatment

Posted by: Vincent Banial for Uniquely Toronto
http://www.uniquelytoronto.com

Disclaimer: Any Trademarks mentioned in this post are owned by the respective Trademark owner. There could be unintentional errors or omissions in this post. This post is subject to change without notice.

Neuroscientist Sara Lazar’s amazing brain scans show meditation can actually change the size of key regions of our brain, improving our memory and making us more empathetic, compassionate, and resilient under stress.

Video is courtesy of the TEDx Talks YouTube page

 

 

Posted by: Vincent Banial for Uniquely Toronto
http://www.uniquelytoronto.com

Disclaimer: Any Trademarks mentioned in this post are owned by the respective Trademark owner. There could be unintentional errors or omissions in this post. Always refer to the official sites to confirm details and any ongoing changes or updates. This post is subject to change without notice.

Susan Cain discusses her book titled “Quiet. The Power of Introverts”

Introverts can be found in Human populations, in Animal populations and among Fish.

Susan Cain details some the extensive research about the differences between Human Extroverts and Human Introverts.

This fascinating video is thanks to Microsoft Research, which is the research division of Microsoft.

Video is courtesy of the UWTV YouTube Channel and Microsoft Research

Posted by: Vincent Banial for Uniquely Toronto
http://www.uniquelytoronto.com

Disclaimer: Any Trademarks mentioned in this post are owned by the respective Trademark owner. There could be unintentional errors or omissions in this post. This post is subject to change without notice.