Category: medical news

How effective is Chemotherapy as a treatment for Cancer?

Posted by Vincent Banial

Chemotherapy can be an effective treatment for Hodgkin’s disease (HD) – a type of lymphoma, which is a blood cancer. Chemotherapy can also be an effective form of treatment for Testicular Cancer.

What about other Cancers?

A study was published in the Dec 2004 issue of the Peer Reviewed Journal called Clinical Oncology, which addressed that question.

The following is taken from the abstract of that research Study :
“The overall contribution of curative and adjuvant cytotoxic chemotherapy to 5-year survival in adults was estimated to be 2.3% in Australia and 2.1% in the USA.”

The conclusion as found in the abstract was:
“it is clear that cytotoxic chemotherapy only makes a minor contribution to cancer survival. To justify the continued funding and availability of drugs used in cytotoxic chemotherapy, a rigorous evaluation of the cost-effectiveness and impact on quality of life is urgently required.”.

Found a link using a web search. The link is below ( you have to copy and paste the URL if you wish to visit their site – as you would from a web search):

http://healingpathwaysmedical.com/docs/chemotherapy-5-year-survival-stats.pdf

Basically that is supposed to be a PDF of the results from that study published on Dec 2004 in Clinical Oncology. It lists over twenty different Cancers and the percentage increases in 5 year survival rates for those patients who received Chemotherapy treatment for said Cancer.

Clinical Oncology had also published another research study in November 2004. You can view an abstract at nature.com by clicking on this line.

The following was the conclusion of the Nov 2004 published in Nov 2004:
“Adjuvant chemotherapy after potentially curative surgery can improve 5-year survival by 4% in patients with early-stage non-small-cell lung cancer (NSCLC, stages IB–IIIA).”.

So after surgery, Chemotherapy may increase the 5 year survival rate in about 4% of the patients. Yes, only 4%.

Using the above quoted studies and being overly generous, in my opinion it may seem that Chemotherapy does not increase the 5 year Survival Rate for about 85% of patients with many forms of Cancer. The exception is that yes it may be a form of effective treatment for Hodgkin’s Disease and for the treatment of Testicular Cancer.

With some Cancers the study chart (see the link to the PDF above) shows Chemotherapy to have zero effect on 5 years Survival Rate.

That leaves the question: Why is Chemotherapy being given to Cancer patients?

Disclaimer: The above is posted for information purposes only. I am not giving Medical Advice. If you have a medical issue please consult with your Licensed Medical Doctor, Specialist or other Medical Professional.

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How Cannabis kills Cancer Cells by Dr, Christina Sanchez

How Cannabis kills Cancer Cells

by Dr, Christina Sanchez

Video is courtesy of the Lincoln Horsley YouTube channel

“Cannabis has been shown to kill cancer cells in the laboratory ” posted by the National Cancer Institue at cancer.gov

Something which has apparently been known in Cancer Research circles, has been formally announced to the public.

“Cannabis has been shown to kill cancer cells in the laboratory” posted by the National Cancer Institue at cancer.gov

Photo of a Marijuana / Cannabis plantPhoto courtesy of the United States Fish and Wildlife Service

The info  below is from the website of the National Cancer Institute (https://www.cancer.gov)

Cannabis and Cannabinoids (PDQ®)–Patient Version

Sections

Overview

  • Cannabis , also known as marijuana, is a plant grown in many parts of the world which produces a resin containing compounds called cannabinoids. Some cannabinoids are psychoactive (acting on the brain and changing mood or consciousness) (see Question 1).
  • The use of Cannabis for medicinal purposes dates back to ancient times (see Question 3).
  • By federal law, the possession of Cannabis is illegal in the United States outside of approved research settings. However, a growing number of states, territories, and the District of Columbia have enacted laws to legalize medical marijuana (see Question 1).
  • In the United States, Cannabis is a controlled substance requiring special licensing for its use (see Question 1 and Question 3).
  • Cannabinoids are active chemicals in Cannabis that cause drug -like effects throughout the body, including the central nervous system and the immune system (see Question 2).
  • The main active cannabinoid in Cannabis is delta-9-THC. Another active cannabinoid is cannabidiol (CBD), which may relieve pain, lower inflammation, and decrease anxiety without causing the “high” of delta-9-THC (see Question 2).
  • Cannabinoids can be taken by mouth, inhaled, or sprayed under the tongue (see Question 5).
  • Cannabis and cannabinoids have been studied in the laboratory and the clinic for relief of pain, nausea and vomiting, anxiety, and loss of appetite (see Question 6 and Question 7).
  • Cannabis and cannabinoids may have benefits in treating the symptoms of cancer or the side effects of cancer therapies. There is growing interest in treating children for symptoms such as nausea with Cannabis and cannabinoids, although studies are limited (see Question 7).
  • Two cannabinoids (dronabinol and nabilone) are drugs approved by the U.S. Food and Drug Administration (FDA) for the prevention or treatment of chemotherapy -related nausea and vomiting (see Question 7 and Question 10).
  • Cannabis has been shown to kill cancer cells in the laboratory (see Question 6).
  • At this time, there is not enough evidence to recommend that patients inhale or ingest Cannabis as a treatment for cancer-related symptoms or side effects of cancer therapy (see Question 7).
  • Cannabis is not approved by the FDA for use as a cancer treatment (see Question 9).

                           ******* end of post from cancer.gov *******

The following are additional links with info related to Cannabis and THC being able to kill Cancer Cells:

Antineoplastic Activity of Cannabinoids
http://www.ukcia.org/research/Antineo…

Cannabinoid Receptor Ligands Mediate Growth Inhibition & Cell Death In Mantle Cell Lymphoma
http://onlinelibrary.wiley.com/doi/10…

Δ9-Tetrahydrocannabinol Induces Apoptosis in Human Prostate PC-3 Cells via a Receptor-Independent Mechanism
http://onlinelibrary.wiley.com/doi/10…

Antitumor Activity of Plant Cannabinoids with Emphasis on the Effect of Cannabidiol on Human Breast Carcinoma
http://jpet.aspetjournals.org/content…

Cannabinoid Receptors As Novel Targets for the Treatment of Melanoma
http://bbml.ucm.es/cannabis/archivos/…

DEA Eliminates 48-Year-Old Monopoly on Research-Grade Marijuana, Clearing Pathway for FDA Approval and Rescheduling

Cannabis plants
Photo of Cannabis plants courtesy of A7nubis and commons.wikimedia.org

Note from Vince: This is am extremely important change as the Cannabis grown by NIDA is an uncommon variety and apparently low in THC.  The FDA could approve a Medical Study of the use of high THC Cannabis in the treatment of Cancer, but NIDA always had the final word. If they approved a medical study (their usual common response was “No”) the study had to use the NIDA supplied Cannabis variety.

WASHINGTON, D.C. — Today, the Drug Enforcement Administration (DEA) announced their intention to grant licenses to additional marijuana growers for research, thereby ending the DEA-imposed 48-year monopoly on federally legal marijuana.  Since 1968, the University of Mississippi, under contract to the National Institute on Drug Abuse (NIDA), has maintained the only facility in the United States with federal permission to grow marijuana for research.

“It’s a complete and total end of the NIDA monopoly! There has been no production monopoly on any other Schedule I substance, like MDMA or LSD—only the cannabis plant. Licensing non-government cannabis producers, and thereby creating a path to FDA approval, will finally facilitate the removal of marijuana from Schedule I, and ultimately allow patients to receive insurance coverage for medical marijuana,” said Rick Doblin, Ph.D., Founder and Executive Director of the Multidisciplinary Association for Psychedelic Studies (MAPS).

MAPS has been working to eliminate this cannabis research blockade since 1999. NIDA’s marijuana is eligible for research, but cannot be sold as a prescription medicine, making it unacceptable to the Food and Drug Administration (FDA) for use in future Phase 3 studies.  Ending the monopoly finally allows for a pathway to FDA approval for marijuana, which would thereby trigger rescheduling.

In 2001, MAPS partnered with University of Massachusetts-Amherst Professor Lyle Craker, Ph.D., to apply for a DEA license and end the monopoly. In 2007, after years of bureaucratic delays and lengthy legal hearings, a DEA Administrative Law Judge (ALJ) recommended that it would be in the public’s interest to grant Craker the license. In 2009, after almost two more years of delays and less than a week before the inauguration of President Obama, former DEA Administrator Michelle Leonhart rejected the ALJ recommendation. In 2011, Craker sued the DEA in the U.S. First Circuit Court of Appeals. In its 2013 decision, the Court uncritically accepted the DEA’s arguments that NIDA’s monopoly provided “an adequate supply produced under adequately competitive conditions.”

Since the 2013 decision, Craker’s argument that NIDA does not have an adequate supply has become significantly more apparent. NIDA has been unable to provide the strains requested for MAPS’ long-delayed Phase 2 clinical trial of smoked marijuana to treat symptoms of posttraumatic stress disorder (PTSD) in 76 U.S. veterans. As a result, the study is proceeding with lower potency marijuana than what MAPS researchers requested.

The DEA has previously claimed that U.S. international treaty obligations under the United Nations Single Convention on Narcotic Drugs (Single Convention) require a federal monopoly, but in April 2016, the State Department released a statement clarifying that the Single Convention does not in fact limit the number of U.S. marijuana producers.

Furthermore, the DEA’s 2009 rejection of the ALJ recommendation to license Craker relied heavily on a U.S. Department of Health and Human Services (HHS) protocol review process, which was eliminated in 2015.

MAPS’ upcoming Phase 2 clinical trial of marijuana for PTSD in veterans is in collaboration with investigators in Phoenix, Arizona, and at Johns Hopkins University, the University of Colorado, and the University of Pennsylvania. The study is funded by a $2.15 million grant to MAPS from the State of Colorado. The study has received full regulatory approval, and will be the first randomized controlled trial of whole plant marijuana as a treatment for PTSD.

Founded in 1986, MAPS is a non-profit research and educational organization working to evaluate the safety and efficacy of botanical marijuana as a potential prescription medicine for specific medical uses approved by the FDA.

MORE INFORMATION

Additional information can be found at maps.org/research/mmj/dea-license.

CONTACT:
Rick Doblin, Ph.D., MAPS Executive Director
rick@maps.org
617-276-7806

Natalie Ginsberg, MAPS Policy & Advocacy Manager
natalie@maps.org
917-520-5531

The above Press Release is courtesy of the Multidisciplinary Association for Psychedelic Studies (MAPS)  whose Mission Sates :

Mission

Founded in 1986, the Multidisciplinary Association for Psychedelic Studies (MAPS) is a 501(c)(3) non-profit research and educational organization that develops medical, legal, and cultural contexts for people to benefit from the careful uses of psychedelics and marijuana.

“Making Peace with Cannabis” by Zach Walsh, PhD, Assistant Professor in the UBC Department of Psychology

This TEDx Talk is titled “Making Peace with Cannabis“. It features Zach Walsh, PhD, who is an Assistant Professor in the UBC Department of Psychology and Co-Director for the Centre for the Advancement of Psychological Science and Law. He is also involved in a current study at UBC which is investigating treating PTSD using Medical Cannabis.

Video is courtesy of the TEDx Talks YouTube channel

How injecting THC and injecting Placebo into veins causes Paranoia, per the results of a poorly designed Oxford University Research Study

Oxford University had posted a News Post titled : “How cannabis causes paranoia”.

Clearly a poorly designed study or one designed to give a negative impression of Cannabis. The study was not about the normal use of Cannabis. It was a study where participants were injected with THC. In the Real World, no one does that.

First of all, they injected THC directly into the veins of participants. IN the Real World, Cannabis users “Do Not” consume Cannabis in that manner. They were only testing THC and not Cannabis. THC is a chemical found in Cannabis, but there are also other chemicals in the Cannabis Plant.

When you smoke or eat Cannabis, it takes time to consume the Joint or Muffin. It takes time for the THC (and other chemicals) to get into the bloodstream. The brain is slowly affected.

When you inject THC, (which “no one” does in the real world) your brain gets hit by the psychoactive chemical THC all at once. There are other Cannabinoids and other chemicals in Cannabis when smoked or eaten. Those other chemicals work with the THC. This test does not represent Cannabis. It represents Injecting THC.

Clearly this was a poorly designed Research Study.

I have never heard of people becoming Paranoid after smoking a joint. Getting the Giggles and laughing at stupid stuff – yes. Getting the Munchies and having a group order Pizza to be delivered – yes. Paranoia – nada.

A clear example is concerts. If you step off to the sidelines and look up you will see a haze of smoke rising from the audience. They are smoking Cannabis – it also has a specific fragrance. I remember Maple Leaf Gardens – same thing rising above the Audience. If large numbers of people were all experiencing Paranoia, they would be running for the exits (or at least a large number would). That has never happened. I have attended and photographed a heck of a lot of concerts and have never seen a mass exit of the audience after they smoked their Cannabis. They all seemed to dance and have fun and enjoyed the music.

Coachella, A recent outdoor concert in the California had an area where free Cannabis was available (to eat and smoke) to those with VIP tickets. Not one single person ran out of that area, because the Cannabis supposedly, as per the failed Oxford study, caused Paranoia.

The other rather interesting thing about that Oxford study is that 30% of the Placebo group “also experienced Paranoia” after being injected with Placebo.

Seems to me that participants lacked Trust in what was being injected into their arms. 50% of those injected with THC experienced Paranoid thoughts. 30% of the participants who were injected with a Placebo also experienced Paranoid thoughts. This is not a normal type of result for a Placebo Group. Interesting how the report of the study did not go into why the 30% of those injected with Placebo had experienced Paranoid thoughts…

I’ll give an example to clarify. Say you wanted to do a study of the effects of drinking two glasses of Red Cabernet Wine each day with your supper. Clearly injecting the equivalent amount of alcohol found in two glasses of Red Wine (12% Alcohol by volume) directly into study participants veins would have a totally different effect than drinking two glasses of wine with supper. No one would design such a sham of study and proclaim the results show the negative effect of drinking two glasses of Red Wine with your supper. Yet this is what was done in the above noted Oxford Study. They injected THC and their News Post was then titled “How Cannabis Causes Paranoia”. They only tested THC (the psychoactive cannabinoid found in Cannabis). They “did not test” using Cannabis. The THC was injected directly into the bloodstream of the participants. No Cannabis was ingested or smoked by the participant. Actually “no Cannabis was ever used” by the Oxford study participants.

That study was funded by the National Health Dept. Medical use of Cannabis is banned by the National Dept of Health. If one wants future Research Funding, does one rock the boat?

Click on this link to visit the University of Oxford website to read their News post titled “How Cannabis Causes Paranoia”.

Here is the URL incase the link has issues: http://www.ox.ac.uk/news/2014-07-16-how-cannabis-causes-paranoia

They could also have called the article
How injecting Placebo causes Paranoia.

Posted by Vincent Banial

Black Pepper Oil inhibited Cancer Cells proliferation by 3.5-86.8%.

Posted by Vincent Banial

The Medical Research Study was conducted by Bioactive Natural Products and Phytoceuticals, Department of Horticulture and National Food Safety and Toxicology Center, Michigan State University, East Lansing, Michigan 48824, USA. The results were authored by Liu Y1, Yadev VR, Aggarwal BB, Nair MG.

Study “results suggest that black pepper and its constituents like hot pepper, exhibit anti-inflammatory, antioxidant and anticancer activities“.

The extracts of black pepper at 200 microg/mL and its compounds at 25 microg/mL inhibited LPO by 45-85%, COX enzymes by 31-80% and cancer cells proliferation by 3.5-86.8%.

Abstract

“Black pepper (Piper nigrum) and hot pepper (Capsicum spp.) are widely used in traditional medicines. Although hot Capsicum spp. extracts and its active principles, capsaicinoids, have been linked with anticancer and anti-inflammatory activities, whether black pepper and its active principle exhibit similar activities is not known. In this study, we have evaluated the antioxidant, anti-inflammatory and anticancer activities of extracts and compounds from black pepper by using proinflammatory transcription factor NF-kappaB, COX-1 and -2 enzymes, human tumor cell proliferation and lipid peroxidation (LPO). The capsaicinoids, the alkylamides, isolated from the hot pepper Scotch Bonnet were also used to compare the bioactivities of alkylamides and piperine from black pepper. All compounds derived from black pepper suppressed TNF-induced NF-kappaB activation, but alkyl amides, compound 4 from black pepper and 5 from hot pepper, were most effective. The human cancer cell proliferation inhibitory activities of piperine and alklyl amides in Capsicum and black pepper were dose dependant. The inhibitory concentrations 50% (IC50) of the alklylamides were in the range 13-200 microg/mL. The extracts of black pepper at 200 microg/mL and its compounds at 25 microg/mL inhibited LPO by 45-85%, COX enzymes by 31-80% and cancer cells proliferation by 3.5-86.8%. Overall, these results suggest that black pepper and its constituents like hot pepper, exhibit anti-inflammatory, antioxidant and anticancer activities.”.

Click on this line to visit the US National Library of Medicine National Institutes of Health PubMed site to read about this research titled “Inhibitory effects of black pepper (Piper nigrum) extracts and compounds on human tumor cell proliferation, cyclooxygenase enzymes, lipid peroxidation and nuclear transcription factor-kappa-B.

Dr.William Courtney, discusses how a massive Inoperable Brain Tumor was remarkably reduced after the 8-month-old baby underwent treatment of Cannabis Oil placed on it’s pacifier.

Cannabis Oil helped an 8-month-old baby with an Inoperable Brain Tumor, said Dr.William Courtney during this taped interview with the Huffington Post.

The Parents “were putting Cannabinoid Oil on the baby’s pacifier twice a day, increasing the dose… And within two months there was a dramatic reduction”.

Dr. Courtney pointed out that the success of the Cannabis approach means that “this child, because of that, is not going to have the long-term side effects that would come from a very high dose of chemotherapy or radiation“”.

Video is courtesy of the Lincoln Horsley YouTube channel

Click on this link to visit the Huffington Post website to read their article about this “Miracle Baby” which was titled “Cannabis For Infant’s Brain Tumor, Doctor Calls Child “A Miracle Baby”“.

Posted by Vincent Banial

 

Researchers found that those who took acetaminophen showed a reduction in empathy.

A new Research Study out of The Ohio State University found that those who took acetaminophen showed a reduction in empathy. They weren’t as concerned about another person’s person’s hurt feelings. The Study was published on May 05 2016 in the journal “Social Congitive and Affective Neuroscience, which is one of the Oxford Journals.

Video is courtesy of the Fox Business YouTube channel

Acetaminophen is the main ingredient in the over the counter pain relief medication called Tylenol.

 

The authors of the study were:

Baldwin Way

Dominik Mischkowski

and Jennifer Crocker

 

Click on this line to visit the Oxford Journals site to view the Study Abstract
From Painkiller to Empathy Killer: Acetaminophen (Paracetamol) Reduces Empathy for Pain

 

Posted by: Vincent Banial
http://www.uniquelytoronto.com

Disclaimer: Any Trademarks mentioned in this post are owned by the respective Trademark owner. There could be unintentional errors or omissions in this post. Always refer to the official sites to confirm details and any ongoing changes or updates. This post is subject to change without notice.