Tagged: Alzheimer’s Disease

New Medical Study sheds light on P. gingivalis colonization in a Human Brain as being the cause of developing Alzheimer’s Disease. The study also found that 100% of patients with Cardiovascular Disease had P. gingivalis arterial colonization.

Having Bad Breath could be a Major Risk Factor in developing Alzheimer’s Disease and Cardiovascular Disease.

A new Medical Study just released sheds light on P. gingivalis colonization in a human Brain as being the cause of developing Alzheimer’s Disease. The study also found that 100% of patients with Cardiovascular Disease had P. gingivalis arterial colonization.

The medical study is published by American Association for the Advancement of ScienceScience Advances. Click on this link to visit the Science Advances site to read the study titled “Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors“.

The following are brief excerpts (you can read the full Study at the link noted above) from this new Research Study:

“The bacterium called gingipains (P. gingivalis) were identified in the brain of Alzheimer’s patients.”

Video is courtesy of the Daily News TD YouTube channel

Oral P. gingivalis infection in mice resulted in brain colonization and increased production of Aβ1–42, a component of amyloid plaques. Further, gingipains were neurotoxic in vivo and in vitro, exerting detrimental effects on tau, a protein needed for normal neuronal function.”

“Alzheimer’s disease (AD) patients exhibit neuroinflammation consistent with infection, including microglial activation, inflammasome activation, complement activation, and altered cytokine profiles (1, 2). Infectious agents have been found in the brain and postulated to be involved with AD, but robust evidence of causation has not been established (3).”

“In Apoe−/− mice, oral infection with P. gingivalis, but not with two other oral bacteria, results in brain infection and activation of the complement pathway (14). In transgenic mice overexpressing mutated human amyloid precursor protein (hAPP-J20), oral infection with P. gingivalis impairs cognitive function, increases the deposition of AD-like plaques, and results in alveolar bone loss compared to control hAPP-J20 mice (15). P. gingivalis lipopolysaccharide has been detected in human AD brains (16), promoting the hypothesis that P. gingivalis infection of the brain plays a role in AD pathogenesis (17).”

“P. gingivalis is mainly found during gingival and periodontal infections; however, it can also be found at low levels in 25% of healthy individuals with no oral disease (18). Transient bacteremia of P. gingivalis can occur during common activities such as brushing, flossing, and chewing, as well as during dental procedures (19), resulting in documented translocation to a variety of tissues including coronary arteries (20), placenta (21), and liver (22).”

“A recent study found that 100% of patients with cardiovascular disease had P. gingivalis arterial colonization.” (23).

Video is courtesy of Joseph R Nemeth DDS & Associates YouTube Channel

Click on this link to visit the New Scientist website to reqd their article titled “We may finally know what causes Alzheimer’s – and how to stop it“.



Scanning ultrasound removes amyloid-β and restores memory in an Alzheimer’s disease mouse model

I used to post about Medical Research in the past. For example, our prior post about research done at Harvard regarding the association between Heart Disease and microbial Human Gut Bacteria had researchers from around the globe visiting this site. Hey life is not just about great looking Exotic Cars, great looking Women and great sounding Music. You should add Medical Research to “round out” that mix.

This post is about research being conducted in Australia, which shows great promise in the treatment of Alzheimers. Apparently some memory loss could be reversed, in mice so far, by using their protocol and Scanning UltraSound.

The study was conducted by : Gerhard Leinenga and Jürgen Götz. Corresponding author. E-mail: j.goetz@uq.edu.au

Their study was published in the peer reviewed journal: Science Translational Medicine 11 Mar 2015: Vol. 7, Issue 278

The article was titled: Research Article Alzheimer’s Disease
Scanning ultrasound removes amyloid-β and restores memory in an Alzheimer’s disease mouse model.

The following is the Abstract (posted for Educational purposes). A link is provided further down to access the complete text and a downloadable PDF.


Amyloid-β (Aβ) peptide has been implicated in the pathogenesis of Alzheimer’s disease (AD). We present a nonpharmacological approach for removing Aβ and restoring memory function in a mouse model of AD in which Aβ is deposited in the brain. We used repeated scanning ultrasound (SUS) treatments of the mouse brain to remove Aβ, without the need for any additional therapeutic agent such as anti-Aβ antibody. Spinning disk confocal microscopy and high-resolution three-dimensional reconstruction revealed extensive internalization of Aβ into the lysosomes of activated microglia in mouse brains subjected to SUS, with no concomitant increase observed in the number of microglia. Plaque burden was reduced in SUS-treated AD mice compared to sham-treated animals, and cleared plaques were observed in 75% of SUS-treated mice. Treated AD mice also displayed improved performance on three memory tasks: the Y-maze, the novel object recognition test, and the active place avoidance task. Our findings suggest that repeated SUS is useful for removing Aβ in the mouse brain without causing overt damage, and should be explored further as a noninvasive method with therapeutic potential in AD.

Click on this line to view the complete text regarding the published results of this study.

Click on this line to view the entire article as a PDF or to Download a PDF copy of the Published material courtesy of the Science Translational Medicine site.

Click on this line to visit the official website of the Queensland Brain Institute at The University of Queensland Australia

Click on this line to visit the Clem Jones Centre for Ageing Dementia Research (CJCADR)



Posted by: Vincent Banial

Disclaimer: Any Trademarks mentioned in this post are owned by the respective Trademark owner. There could be unintentional errors or omissions in this post. Always refer to the official sites to confirm details and any ongoing changes or updates. This post is subject to change without notice. The Study Abstract has been included in this post for Educational Purposes and so is covered by the Fair Use component of Copyright. Uniquely Toronto makes no claims regarding the copyright or other rights to the published material. Also complete links have been included to the Science Translational Medicine site.

Fasting may have postive effects on Human Brains. This Ted Talk is presented by Neuroscientist Mark Mattson

A very interesting Ted Talk about the positive effects of fasting on the Brain. It is presented by Mark Mattson is the current Chief of the Laboratory of Neurosciences at the National Institute on Aging.

Video is courtesy of the TEDx Talks YouTube channel

From the research which Mark Mattson is undertaking, Fasting could benefit those suffering with Alzheimer’s Disease & Dementia.

As the number of Alzheimer’s Disease & Dementia patients spiral upwards, the research on Fasting could prove most important.

Posted by: Vincent Banial

Disclaimer: Any Trademarks mentioned in this post are owned by the respective Trademark owner.