I used to post about Medical Research in the past. For example, our prior post about research done at Harvard regarding the association between Heart Disease and microbial Human Gut Bacteria had researchers from around the globe visiting this site. Hey life is not just about great looking Exotic Cars, great looking Women and great sounding Music. You should add Medical Research to “round out” that mix.
This post is about research being conducted in Australia, which shows great promise in the treatment of Alzheimers. Apparently some memory loss could be reversed, in mice so far, by using their protocol and Scanning UltraSound.
Their study was published in the peer reviewed journal: Science Translational Medicine 11 Mar 2015: Vol. 7, Issue 278
The article was titled: Research Article Alzheimer’s Disease
Scanning ultrasound removes amyloid-β and restores memory in an Alzheimer’s disease mouse model.
The following is the Abstract (posted for Educational purposes). A link is provided further down to access the complete text and a downloadable PDF.
Amyloid-β (Aβ) peptide has been implicated in the pathogenesis of Alzheimer’s disease (AD). We present a nonpharmacological approach for removing Aβ and restoring memory function in a mouse model of AD in which Aβ is deposited in the brain. We used repeated scanning ultrasound (SUS) treatments of the mouse brain to remove Aβ, without the need for any additional therapeutic agent such as anti-Aβ antibody. Spinning disk confocal microscopy and high-resolution three-dimensional reconstruction revealed extensive internalization of Aβ into the lysosomes of activated microglia in mouse brains subjected to SUS, with no concomitant increase observed in the number of microglia. Plaque burden was reduced in SUS-treated AD mice compared to sham-treated animals, and cleared plaques were observed in 75% of SUS-treated mice. Treated AD mice also displayed improved performance on three memory tasks: the Y-maze, the novel object recognition test, and the active place avoidance task. Our findings suggest that repeated SUS is useful for removing Aβ in the mouse brain without causing overt damage, and should be explored further as a noninvasive method with therapeutic potential in AD.
Posted by: Vincent Banial
Disclaimer: Any Trademarks mentioned in this post are owned by the respective Trademark owner. There could be unintentional errors or omissions in this post. Always refer to the official sites to confirm details and any ongoing changes or updates. This post is subject to change without notice. The Study Abstract has been included in this post for Educational Purposes and so is covered by the Fair Use component of Copyright. Uniquely Toronto makes no claims regarding the copyright or other rights to the published material. Also complete links have been included to the Science Translational Medicine site.
A very interesting Ted Talk about the positive effects of fasting on the Brain. It is presented by Mark Mattson is the current Chief of the Laboratory of Neurosciences at the National Institute on Aging.
Video is courtesy of the TEDx Talks YouTube channel
From the research which Mark Mattson is undertaking, Fasting could benefit those suffering with Alzheimer’s Disease & Dementia.
As the number of Alzheimer’s Disease & Dementia patients spiral upwards, the research on Fasting could prove most important.
Posted by: Vincent Banial
Disclaimer: Any Trademarks mentioned in this post are owned by the respective Trademark owner.