Category: Alzheimer’s

New Medical Study sheds light on P. gingivalis colonization in a Human Brain as being the cause of developing Alzheimer’s Disease. The study also found that 100% of patients with Cardiovascular Disease had P. gingivalis arterial colonization.

Having Bad Breath could be a Major Risk Factor in developing Alzheimer’s Disease and Cardiovascular Disease.

A new Medical Study just released sheds light on P. gingivalis colonization in a human Brain as being the cause of developing Alzheimer’s Disease. The study also found that 100% of patients with Cardiovascular Disease had P. gingivalis arterial colonization.

The medical study is published by American Association for the Advancement of ScienceScience Advances. Click on this link to visit the Science Advances site to read the study titled “Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors“.

The following are brief excerpts (you can read the full Study at the link noted above) from this new Research Study:

“The bacterium called gingipains (P. gingivalis) were identified in the brain of Alzheimer’s patients.”

Video is courtesy of OSH News Network YouTube Channel

Oral P. gingivalis infection in mice resulted in brain colonization and increased production of Aβ1–42, a component of amyloid plaques. Further, gingipains were neurotoxic in vivo and in vitro, exerting detrimental effects on tau, a protein needed for normal neuronal function.”

“Alzheimer’s disease (AD) patients exhibit neuroinflammation consistent with infection, including microglial activation, inflammasome activation, complement activation, and altered cytokine profiles (1, 2). Infectious agents have been found in the brain and postulated to be involved with AD, but robust evidence of causation has not been established (3).”

“In Apoe−/− mice, oral infection with P. gingivalis, but not with two other oral bacteria, results in brain infection and activation of the complement pathway (14). In transgenic mice overexpressing mutated human amyloid precursor protein (hAPP-J20), oral infection with P. gingivalis impairs cognitive function, increases the deposition of AD-like plaques, and results in alveolar bone loss compared to control hAPP-J20 mice (15). P. gingivalis lipopolysaccharide has been detected in human AD brains (16), promoting the hypothesis that P. gingivalis infection of the brain plays a role in AD pathogenesis (17).”

“P. gingivalis is mainly found during gingival and periodontal infections; however, it can also be found at low levels in 25% of healthy individuals with no oral disease (18). Transient bacteremia of P. gingivalis can occur during common activities such as brushing, flossing, and chewing, as well as during dental procedures (19), resulting in documented translocation to a variety of tissues including coronary arteries (20), placenta (21), and liver (22).”

“A recent study found that 100% of patients with cardiovascular disease had P. gingivalis arterial colonization.” (23).

Video is courtesy of John Douillard YouTube Channel

Click on this link to visit the New Scientist website to reqd their article titled “We may finally know what causes Alzheimer’s – and how to stop it“.

Posted by: Vincent Banial

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New Research at Salk Institute shows that Cannabinoids remove plaque-forming Alzheimer’s proteins from brain cells

Medical Cannabis could possibly halt Alzheimer’s and could maybe even reverse the damage caused by Alzheimer’s. That is my interpretation of the results from a medical study conducted by Salk Institute Scientists.

The following is from their News Release:

Salk Institute scientists have found preliminary evidence that tetrahydrocannabinol (THC) and other compounds found in marijuana can promote the cellular removal of amyloid beta, a toxic protein associated with Alzheimer’s disease.”

“Although other studies have offered evidence that cannabinoids might be neuroprotective against the symptoms of Alzheimer’s, we believe our study is the first to demonstrate that cannabinoids affect both inflammation and amyloid beta accumulation in nerve cells,” says Salk Professor David Schubert, the senior author of the paper.”

I am not giving any medical Advice with the following statements. Maybe discuss with the Medical Doctor taking care of a family member suffering from Alzheimer’s.  Ask the Doctor for a prescription for Medical Cannabis, which is available in Canada and many states in America. Working with their Medical Doctor, one could maybe create your own private human trial under your Doctor’s supervision. In my mind, the risk is extremely low. Keep notes and search the internet for Cogniition Tests (Alzheimer’s Associations are a good resource) . Under the care of a Medical Doctor, testing to see if Medical Cannabis could reduce the effects of Alzheimer’s and improve cognition, in my opinion, has a high safety factor. For example, no one has died from smoking or eating too much Cannabis. On the other hand, thousands of people have died due to major Liver damage caused by overdosing on medication such as Tylenol.

Click on the following link to read the News Release about the new finding from the Salk Institute website.

Click on this link to visit the Journal  Aging and Mechanisms of Disease to read the published Salk Institute Study titled :Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids

Title: Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids
Author: Antonio Currais, Oswald Quehenberger, Aaron M Armando, Daniel Daugherty, Pam Maher et al.
Publication: npj Aging and Mechanisms of Disease
Publisher: Nature Publishing Group
Date: Jun 23, 2016
Copyright © 2016, Rights Managed by Nature Publishing Group

Click on this link to download a PDF copy of the study from the site of the Journal