Category: Gerhard Leinenga

Scanning ultrasound removes amyloid-β and restores memory in an Alzheimer’s disease mouse model

I used to post about Medical Research in the past. For example, our prior post about research done at Harvard regarding the association between Heart Disease and microbial Human Gut Bacteria had researchers from around the globe visiting this site. Hey life is not just about great looking Exotic Cars, great looking Women and great sounding Music. You should add Medical Research to “round out” that mix.

This post is about research being conducted in Australia, which shows great promise in the treatment of Alzheimers. Apparently some memory loss could be reversed, in mice so far, by using their protocol and Scanning UltraSound.

The study was conducted by : Gerhard Leinenga and Jürgen Götz. Corresponding author. E-mail:

Their study was published in the peer reviewed journal: Science Translational Medicine 11 Mar 2015: Vol. 7, Issue 278

The article was titled: Research Article Alzheimer’s Disease
Scanning ultrasound removes amyloid-β and restores memory in an Alzheimer’s disease mouse model.

The following is the Abstract (posted for Educational purposes). A link is provided further down to access the complete text and a downloadable PDF.


Amyloid-β (Aβ) peptide has been implicated in the pathogenesis of Alzheimer’s disease (AD). We present a nonpharmacological approach for removing Aβ and restoring memory function in a mouse model of AD in which Aβ is deposited in the brain. We used repeated scanning ultrasound (SUS) treatments of the mouse brain to remove Aβ, without the need for any additional therapeutic agent such as anti-Aβ antibody. Spinning disk confocal microscopy and high-resolution three-dimensional reconstruction revealed extensive internalization of Aβ into the lysosomes of activated microglia in mouse brains subjected to SUS, with no concomitant increase observed in the number of microglia. Plaque burden was reduced in SUS-treated AD mice compared to sham-treated animals, and cleared plaques were observed in 75% of SUS-treated mice. Treated AD mice also displayed improved performance on three memory tasks: the Y-maze, the novel object recognition test, and the active place avoidance task. Our findings suggest that repeated SUS is useful for removing Aβ in the mouse brain without causing overt damage, and should be explored further as a noninvasive method with therapeutic potential in AD.

Click on this line to view the complete text regarding the published results of this study.

Click on this line to view the entire article as a PDF or to Download a PDF copy of the Published material courtesy of the Science Translational Medicine site.

Click on this line to visit the official website of the Queensland Brain Institute at The University of Queensland Australia

Click on this line to visit the Clem Jones Centre for Ageing Dementia Research (CJCADR)



Posted by: Vincent Banial

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