Category: Medical Research

How effective is Chemotherapy as a treatment for Cancer?

Posted by Vincent Banial

Chemotherapy can be an effective treatment for Hodgkin’s disease (HD) – a type of lymphoma, which is a blood cancer. Chemotherapy can also be an effective form of treatment for Testicular Cancer.

What about other Cancers?

A study was published in the Dec 2004 issue of the Peer Reviewed Journal called Clinical Oncology, which addressed that question.

The following is taken from the abstract of that research Study :
“The overall contribution of curative and adjuvant cytotoxic chemotherapy to 5-year survival in adults was estimated to be 2.3% in Australia and 2.1% in the USA.”

The conclusion as found in the abstract was:
“it is clear that cytotoxic chemotherapy only makes a minor contribution to cancer survival. To justify the continued funding and availability of drugs used in cytotoxic chemotherapy, a rigorous evaluation of the cost-effectiveness and impact on quality of life is urgently required.”.

Found a link using a web search. The link is below ( you have to copy and paste the URL if you wish to visit their site – as you would from a web search):

http://healingpathwaysmedical.com/docs/chemotherapy-5-year-survival-stats.pdf

Basically that is supposed to be a PDF of the results from that study published on Dec 2004 in Clinical Oncology. It lists over twenty different Cancers and the percentage increases in 5 year survival rates for those patients who received Chemotherapy treatment for said Cancer.

Clinical Oncology had also published another research study in November 2004. You can view an abstract at nature.com by clicking on this line.

The following was the conclusion of the Nov 2004 published in Nov 2004:
“Adjuvant chemotherapy after potentially curative surgery can improve 5-year survival by 4% in patients with early-stage non-small-cell lung cancer (NSCLC, stages IB–IIIA).”.

So after surgery, Chemotherapy may increase the 5 year survival rate in about 4% of the patients. Yes, only 4%.

Using the above quoted studies and being overly generous, in my opinion it may seem that Chemotherapy does not increase the 5 year Survival Rate for about 85% of patients with many forms of Cancer. The exception is that yes it may be a form of effective treatment for Hodgkin’s Disease and for the treatment of Testicular Cancer.

With some Cancers the study chart (see the link to the PDF above) shows Chemotherapy to have zero effect on 5 years Survival Rate.

That leaves the question: Why is Chemotherapy being given to Cancer patients?

Disclaimer: The above is posted for information purposes only. I am not giving Medical Advice. If you have a medical issue please consult with your Licensed Medical Doctor, Specialist or other Medical Professional.

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How Cannabis kills Cancer Cells by Dr, Christina Sanchez

How Cannabis kills Cancer Cells

by Dr, Christina Sanchez

Video is courtesy of the Lincoln Horsley YouTube channel

“Cannabis has been shown to kill cancer cells in the laboratory ” posted by the National Cancer Institue at cancer.gov

Something which has apparently been known in Cancer Research circles, has been formally announced to the public.

“Cannabis has been shown to kill cancer cells in the laboratory” posted by the National Cancer Institue at cancer.gov

Photo of a Marijuana / Cannabis plantPhoto courtesy of the United States Fish and Wildlife Service

The info  below is from the website of the National Cancer Institute (https://www.cancer.gov)

Cannabis and Cannabinoids (PDQ®)–Patient Version

Sections

Overview

  • Cannabis , also known as marijuana, is a plant grown in many parts of the world which produces a resin containing compounds called cannabinoids. Some cannabinoids are psychoactive (acting on the brain and changing mood or consciousness) (see Question 1).
  • The use of Cannabis for medicinal purposes dates back to ancient times (see Question 3).
  • By federal law, the possession of Cannabis is illegal in the United States outside of approved research settings. However, a growing number of states, territories, and the District of Columbia have enacted laws to legalize medical marijuana (see Question 1).
  • In the United States, Cannabis is a controlled substance requiring special licensing for its use (see Question 1 and Question 3).
  • Cannabinoids are active chemicals in Cannabis that cause drug -like effects throughout the body, including the central nervous system and the immune system (see Question 2).
  • The main active cannabinoid in Cannabis is delta-9-THC. Another active cannabinoid is cannabidiol (CBD), which may relieve pain, lower inflammation, and decrease anxiety without causing the “high” of delta-9-THC (see Question 2).
  • Cannabinoids can be taken by mouth, inhaled, or sprayed under the tongue (see Question 5).
  • Cannabis and cannabinoids have been studied in the laboratory and the clinic for relief of pain, nausea and vomiting, anxiety, and loss of appetite (see Question 6 and Question 7).
  • Cannabis and cannabinoids may have benefits in treating the symptoms of cancer or the side effects of cancer therapies. There is growing interest in treating children for symptoms such as nausea with Cannabis and cannabinoids, although studies are limited (see Question 7).
  • Two cannabinoids (dronabinol and nabilone) are drugs approved by the U.S. Food and Drug Administration (FDA) for the prevention or treatment of chemotherapy -related nausea and vomiting (see Question 7 and Question 10).
  • Cannabis has been shown to kill cancer cells in the laboratory (see Question 6).
  • At this time, there is not enough evidence to recommend that patients inhale or ingest Cannabis as a treatment for cancer-related symptoms or side effects of cancer therapy (see Question 7).
  • Cannabis is not approved by the FDA for use as a cancer treatment (see Question 9).

                           ******* end of post from cancer.gov *******

The following are additional links with info related to Cannabis and THC being able to kill Cancer Cells:

Antineoplastic Activity of Cannabinoids
http://www.ukcia.org/research/Antineo…

Cannabinoid Receptor Ligands Mediate Growth Inhibition & Cell Death In Mantle Cell Lymphoma
http://onlinelibrary.wiley.com/doi/10…

Δ9-Tetrahydrocannabinol Induces Apoptosis in Human Prostate PC-3 Cells via a Receptor-Independent Mechanism
http://onlinelibrary.wiley.com/doi/10…

Antitumor Activity of Plant Cannabinoids with Emphasis on the Effect of Cannabidiol on Human Breast Carcinoma
http://jpet.aspetjournals.org/content…

Cannabinoid Receptors As Novel Targets for the Treatment of Melanoma
http://bbml.ucm.es/cannabis/archivos/…

DEA Eliminates 48-Year-Old Monopoly on Research-Grade Marijuana, Clearing Pathway for FDA Approval and Rescheduling

Cannabis plants
Photo of Cannabis plants courtesy of A7nubis and commons.wikimedia.org

Note from Vince: This is am extremely important change as the Cannabis grown by NIDA is an uncommon variety and apparently low in THC.  The FDA could approve a Medical Study of the use of high THC Cannabis in the treatment of Cancer, but NIDA always had the final word. If they approved a medical study (their usual common response was “No”) the study had to use the NIDA supplied Cannabis variety.

WASHINGTON, D.C. — Today, the Drug Enforcement Administration (DEA) announced their intention to grant licenses to additional marijuana growers for research, thereby ending the DEA-imposed 48-year monopoly on federally legal marijuana.  Since 1968, the University of Mississippi, under contract to the National Institute on Drug Abuse (NIDA), has maintained the only facility in the United States with federal permission to grow marijuana for research.

“It’s a complete and total end of the NIDA monopoly! There has been no production monopoly on any other Schedule I substance, like MDMA or LSD—only the cannabis plant. Licensing non-government cannabis producers, and thereby creating a path to FDA approval, will finally facilitate the removal of marijuana from Schedule I, and ultimately allow patients to receive insurance coverage for medical marijuana,” said Rick Doblin, Ph.D., Founder and Executive Director of the Multidisciplinary Association for Psychedelic Studies (MAPS).

MAPS has been working to eliminate this cannabis research blockade since 1999. NIDA’s marijuana is eligible for research, but cannot be sold as a prescription medicine, making it unacceptable to the Food and Drug Administration (FDA) for use in future Phase 3 studies.  Ending the monopoly finally allows for a pathway to FDA approval for marijuana, which would thereby trigger rescheduling.

In 2001, MAPS partnered with University of Massachusetts-Amherst Professor Lyle Craker, Ph.D., to apply for a DEA license and end the monopoly. In 2007, after years of bureaucratic delays and lengthy legal hearings, a DEA Administrative Law Judge (ALJ) recommended that it would be in the public’s interest to grant Craker the license. In 2009, after almost two more years of delays and less than a week before the inauguration of President Obama, former DEA Administrator Michelle Leonhart rejected the ALJ recommendation. In 2011, Craker sued the DEA in the U.S. First Circuit Court of Appeals. In its 2013 decision, the Court uncritically accepted the DEA’s arguments that NIDA’s monopoly provided “an adequate supply produced under adequately competitive conditions.”

Since the 2013 decision, Craker’s argument that NIDA does not have an adequate supply has become significantly more apparent. NIDA has been unable to provide the strains requested for MAPS’ long-delayed Phase 2 clinical trial of smoked marijuana to treat symptoms of posttraumatic stress disorder (PTSD) in 76 U.S. veterans. As a result, the study is proceeding with lower potency marijuana than what MAPS researchers requested.

The DEA has previously claimed that U.S. international treaty obligations under the United Nations Single Convention on Narcotic Drugs (Single Convention) require a federal monopoly, but in April 2016, the State Department released a statement clarifying that the Single Convention does not in fact limit the number of U.S. marijuana producers.

Furthermore, the DEA’s 2009 rejection of the ALJ recommendation to license Craker relied heavily on a U.S. Department of Health and Human Services (HHS) protocol review process, which was eliminated in 2015.

MAPS’ upcoming Phase 2 clinical trial of marijuana for PTSD in veterans is in collaboration with investigators in Phoenix, Arizona, and at Johns Hopkins University, the University of Colorado, and the University of Pennsylvania. The study is funded by a $2.15 million grant to MAPS from the State of Colorado. The study has received full regulatory approval, and will be the first randomized controlled trial of whole plant marijuana as a treatment for PTSD.

Founded in 1986, MAPS is a non-profit research and educational organization working to evaluate the safety and efficacy of botanical marijuana as a potential prescription medicine for specific medical uses approved by the FDA.

MORE INFORMATION

Additional information can be found at maps.org/research/mmj/dea-license.

CONTACT:
Rick Doblin, Ph.D., MAPS Executive Director
rick@maps.org
617-276-7806

Natalie Ginsberg, MAPS Policy & Advocacy Manager
natalie@maps.org
917-520-5531

The above Press Release is courtesy of the Multidisciplinary Association for Psychedelic Studies (MAPS)  whose Mission Sates :

Mission

Founded in 1986, the Multidisciplinary Association for Psychedelic Studies (MAPS) is a 501(c)(3) non-profit research and educational organization that develops medical, legal, and cultural contexts for people to benefit from the careful uses of psychedelics and marijuana.

“Making Peace with Cannabis” by Zach Walsh, PhD, Assistant Professor in the UBC Department of Psychology

This TEDx Talk is titled “Making Peace with Cannabis“. It features Zach Walsh, PhD, who is an Assistant Professor in the UBC Department of Psychology and Co-Director for the Centre for the Advancement of Psychological Science and Law. He is also involved in a current study at UBC which is investigating treating PTSD using Medical Cannabis.

Video is courtesy of the TEDx Talks YouTube channel

How injecting THC and injecting Placebo into veins causes Paranoia, per the results of a poorly designed Oxford University Research Study

Oxford University had posted a News Post titled : “How cannabis causes paranoia”.

Clearly a poorly designed study or one designed to give a negative impression of Cannabis. The study was not about the normal use of Cannabis. It was a study where participants were injected with THC. In the Real World, no one does that.

First of all, they injected THC directly into the veins of participants. IN the Real World, Cannabis users “Do Not” consume Cannabis in that manner. They were only testing THC and not Cannabis. THC is a chemical found in Cannabis, but there are also other chemicals in the Cannabis Plant.

When you smoke or eat Cannabis, it takes time to consume the Joint or Muffin. It takes time for the THC (and other chemicals) to get into the bloodstream. The brain is slowly affected.

When you inject THC, (which “no one” does in the real world) your brain gets hit by the psychoactive chemical THC all at once. There are other Cannabinoids and other chemicals in Cannabis when smoked or eaten. Those other chemicals work with the THC. This test does not represent Cannabis. It represents Injecting THC.

Clearly this was a poorly designed Research Study.

I have never heard of people becoming Paranoid after smoking a joint. Getting the Giggles and laughing at stupid stuff – yes. Getting the Munchies and having a group order Pizza to be delivered – yes. Paranoia – nada.

A clear example is concerts. If you step off to the sidelines and look up you will see a haze of smoke rising from the audience. They are smoking Cannabis – it also has a specific fragrance. I remember Maple Leaf Gardens – same thing rising above the Audience. If large numbers of people were all experiencing Paranoia, they would be running for the exits (or at least a large number would). That has never happened. I have attended and photographed a heck of a lot of concerts and have never seen a mass exit of the audience after they smoked their Cannabis. They all seemed to dance and have fun and enjoyed the music.

Coachella, A recent outdoor concert in the California had an area where free Cannabis was available (to eat and smoke) to those with VIP tickets. Not one single person ran out of that area, because the Cannabis supposedly, as per the failed Oxford study, caused Paranoia.

The other rather interesting thing about that Oxford study is that 30% of the Placebo group “also experienced Paranoia” after being injected with Placebo.

Seems to me that participants lacked Trust in what was being injected into their arms. 50% of those injected with THC experienced Paranoid thoughts. 30% of the participants who were injected with a Placebo also experienced Paranoid thoughts. This is not a normal type of result for a Placebo Group. Interesting how the report of the study did not go into why the 30% of those injected with Placebo had experienced Paranoid thoughts…

I’ll give an example to clarify. Say you wanted to do a study of the effects of drinking two glasses of Red Cabernet Wine each day with your supper. Clearly injecting the equivalent amount of alcohol found in two glasses of Red Wine (12% Alcohol by volume) directly into study participants veins would have a totally different effect than drinking two glasses of wine with supper. No one would design such a sham of study and proclaim the results show the negative effect of drinking two glasses of Red Wine with your supper. Yet this is what was done in the above noted Oxford Study. They injected THC and their News Post was then titled “How Cannabis Causes Paranoia”. They only tested THC (the psychoactive cannabinoid found in Cannabis). They “did not test” using Cannabis. The THC was injected directly into the bloodstream of the participants. No Cannabis was ingested or smoked by the participant. Actually “no Cannabis was ever used” by the Oxford study participants.

That study was funded by the National Health Dept. Medical use of Cannabis is banned by the National Dept of Health. If one wants future Research Funding, does one rock the boat?

Click on this link to visit the University of Oxford website to read their News post titled “How Cannabis Causes Paranoia”.

Here is the URL incase the link has issues: http://www.ox.ac.uk/news/2014-07-16-how-cannabis-causes-paranoia

They could also have called the article
How injecting Placebo causes Paranoia.

Posted by Vincent Banial

Black Pepper Oil inhibited Cancer Cells proliferation by 3.5-86.8%.

Posted by Vincent Banial

The Medical Research Study was conducted by Bioactive Natural Products and Phytoceuticals, Department of Horticulture and National Food Safety and Toxicology Center, Michigan State University, East Lansing, Michigan 48824, USA. The results were authored by Liu Y1, Yadev VR, Aggarwal BB, Nair MG.

Study “results suggest that black pepper and its constituents like hot pepper, exhibit anti-inflammatory, antioxidant and anticancer activities“.

The extracts of black pepper at 200 microg/mL and its compounds at 25 microg/mL inhibited LPO by 45-85%, COX enzymes by 31-80% and cancer cells proliferation by 3.5-86.8%.

Abstract

“Black pepper (Piper nigrum) and hot pepper (Capsicum spp.) are widely used in traditional medicines. Although hot Capsicum spp. extracts and its active principles, capsaicinoids, have been linked with anticancer and anti-inflammatory activities, whether black pepper and its active principle exhibit similar activities is not known. In this study, we have evaluated the antioxidant, anti-inflammatory and anticancer activities of extracts and compounds from black pepper by using proinflammatory transcription factor NF-kappaB, COX-1 and -2 enzymes, human tumor cell proliferation and lipid peroxidation (LPO). The capsaicinoids, the alkylamides, isolated from the hot pepper Scotch Bonnet were also used to compare the bioactivities of alkylamides and piperine from black pepper. All compounds derived from black pepper suppressed TNF-induced NF-kappaB activation, but alkyl amides, compound 4 from black pepper and 5 from hot pepper, were most effective. The human cancer cell proliferation inhibitory activities of piperine and alklyl amides in Capsicum and black pepper were dose dependant. The inhibitory concentrations 50% (IC50) of the alklylamides were in the range 13-200 microg/mL. The extracts of black pepper at 200 microg/mL and its compounds at 25 microg/mL inhibited LPO by 45-85%, COX enzymes by 31-80% and cancer cells proliferation by 3.5-86.8%. Overall, these results suggest that black pepper and its constituents like hot pepper, exhibit anti-inflammatory, antioxidant and anticancer activities.”.

Click on this line to visit the US National Library of Medicine National Institutes of Health PubMed site to read about this research titled “Inhibitory effects of black pepper (Piper nigrum) extracts and compounds on human tumor cell proliferation, cyclooxygenase enzymes, lipid peroxidation and nuclear transcription factor-kappa-B.

Metabolically starving Cancer Cells through diet and compressed oxygen, replacing chemotherapy, surgery, or radiation is a therapy developed by Dr. Dominic D’Agostino

Dr. Dominic D’Agostino is an Assistant Professor at the University of South Florida College Of Medicine, Molecular Pharmacology & Physiology where he develops and tests Metabolic Therapies, including alternative energy substrates and ketogenic agents for neurological disorders, Cancer and wound healing.

While studying the effects of gasses on the brains of Navy Seal divers, he developed an approach for metabolically starving Cancer Cells through diet and compressed oxygen, replacing chemotherapy, surgery, or radiation.

Video is courtesy of the TEDx Talks YouTube channel

Click on this link to visit the official US Government PubMed site to view research findings published by Dr. Dominic D’Agostino titled “Press-pulse: a novel therapeutic strategy for the metabolic management of cancer.”

Click on this link to visit the official site of Dr. Dominic D’Agostino.

Posted by Vincent Banial

 

New Research at Salk Institute shows that Cannabinoids remove plaque-forming Alzheimer’s proteins from brain cells

Medical Cannabis could possibly halt Alzheimer’s and could maybe even reverse the damage caused by Alzheimer’s. That is my interpretation of the results from a medical study conducted by Salk Institute Scientists.

The following is from their News Release:

Salk Institute scientists have found preliminary evidence that tetrahydrocannabinol (THC) and other compounds found in marijuana can promote the cellular removal of amyloid beta, a toxic protein associated with Alzheimer’s disease.”

“Although other studies have offered evidence that cannabinoids might be neuroprotective against the symptoms of Alzheimer’s, we believe our study is the first to demonstrate that cannabinoids affect both inflammation and amyloid beta accumulation in nerve cells,” says Salk Professor David Schubert, the senior author of the paper.”

I am not giving any medical Advice with the following statements. Maybe discuss with the Medical Doctor taking care of a family member suffering from Alzheimer’s.  Ask the Doctor for a prescription for Medical Cannabis, which is available in Canada and many states in America. Working with their Medical Doctor, one could maybe create your own private human trial under your Doctor’s supervision. In my mind, the risk is extremely low. Keep notes and search the internet for Cogniition Tests (Alzheimer’s Associations are a good resource) . Under the care of a Medical Doctor, testing to see if Medical Cannabis could reduce the effects of Alzheimer’s and improve cognition, in my opinion, has a high safety factor. For example, no one has died from smoking or eating too much Cannabis. On the other hand, thousands of people have died due to major Liver damage caused by overdosing on medication such as Tylenol.

Click on the following link to read the News Release about the new finding from the Salk Institute website.

Click on this link to visit the Journal  Aging and Mechanisms of Disease to read the published Salk Institute Study titled :Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids

Title: Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids
Author: Antonio Currais, Oswald Quehenberger, Aaron M Armando, Daniel Daugherty, Pam Maher et al.
Publication: npj Aging and Mechanisms of Disease
Publisher: Nature Publishing Group
Date: Jun 23, 2016
Copyright © 2016, Rights Managed by Nature Publishing Group

Click on this link to download a PDF copy of the study from the site of the Journal 

New Medical Study: “Creating beauty: Creativity compensates for low physical attractiveness when individuals assess the attractiveness of social and romantic partners” by Christopher D. Watkins

If you are a lucky male who was born incredibly handsome, you may want to skip this discussion of a new Scientific Study. On the other hand, if you are an average or below average looking male, this new Study titled: “Creating beauty: Creativity compensates for low physical attractiveness when individuals assess the attractiveness of social and romantic partners” by Christopher D. Watkins of Abertay University in Scotland may just help shed light on ways to improve your romantic life or maybe even get one.

I run this blog and shoot photographs of events such as shows and concerts. I do it for the fun of it. Today I learned that there are other benefits to being “creative” and displaying your creativity. My creativity will compensate for my “not being” a total male hunk and  Eye Candy in a woman’s eyes.  That’s not to say that I’m ugly, just average looking. Ask any guy if they would prefer a beautiful girlfriend or one which looks just average. Surprise, the same goes for women. Humans prefer beauty in their partners. It is instinctive and meant to help continue with the survival of the human species.

This newly published Research Study conducted by Christopher Watkins of Abertay University in Scotland helps to explain some of the extremely gorgeous women that I have dated in my life. The downside of dating a really great looking woman is that any other guys in the same room will be doing body scans of your girlfriend.

So how is that a physically gorgeous female super model would even go out with an average looking guy like me?

This new scientific study

Unfortunately, this does not apply to women. Displays of creativity by an average looking women, will not enhance her appeal to the eyes of a male. Us males are rather fixated on physical beauty. Your average looking female can have tons of “inner beauty” and in the end that is far more important. But males generally look at the outer packaging.

Click on this link to download a PDF copy of the published Research Study titled “Creating beauty: Creativity compensates for low physical attractiveness when individuals assess the attractiveness of social and romantic partners” by Christopher D. Watkins

Enough of Vince’s banter, I know that the readers here can’t wait to view this new Research Study, which is below. Please note that I am posting this new research with permission, but that does not mean that Christopher D. Watkins  or Abertay University in Scotland in any way endorse the Uniquely Toronto website or Vincent Banial.

Creating beauty: creativity compensates for low physical attractiveness when individuals assess the attractiveness of social and romantic partners

Christopher D. Watkins

Abstract

Although creativity is attractive in a potential mate, it is unclear (i) whether the effects of creativity on attractiveness generalize to other social contexts and (ii) whether creativity has equivalent effects on men’s and women’s attractiveness. As social knowledge of creativity may either enhance or ‘offset’ the appeal of social partners who differ in physical attractiveness, three repeated measures experiments were conducted to directly address these issues. Here, participants rated a series of face–text pairs for attractiveness on trials that differed in one of four combinations of facial attractiveness (attractive and less attractive) and creativity (creative and less creative), rating story-tellers in two experiments (short interpretations of an identical painting) and creative ideas in a further experiment (alternative uses for an everyday object). Regardless of the sex of the judge, creativity and facial attractiveness had independent effects on men’s overall attractiveness (initial experiment) and, in further experiments, more substantial effects on the attractiveness of men with less attractive faces than men with attractive faces (when using a different measure of creativity) and specific effects on the attractiveness of individuals with less attractive faces (when using different face stimuli). Collectively, across three experiments, these findings suggest that creativity may compensate for putative cues to lower biological ‘quality’ and that the benefits of creativity to social groups more generally enhance attraction to creative men (in two experiments) and creative men and women (one experiment). More broadly, the data suggest that species can integrate knowledge of cognitive intelligence with visual cues to biological ‘quality’ to facilitate mate and/or ally choice.

Continue reading

Venclexta (Venetoclax) granted U.S. FDA approval for the treatment of patients with Chronic Lymphocytic Leukemia (CLL)

Venclexta (Venetoclax) is the first FDA-approved treatment that targets the B-cell lymphoma 2 (BCL-2) protein, which supports cancer cell growth and is over-expressed in many patients with Chronic Lymphocytic Leukemia (CLL).

The patient must have been previously treated with at least one other approved treatment protocol without success. Venclexta (Venetoclax) may be the Holy Mary drug to try when everything else failed.

Patients on the Venclexta (Venetoclax) regime must be monitored as their can be severe side effects. During Human Trails a number of patients developed upper respiratory issues such as Pneumonia.

Patients also have to maintain a level of hydration – 1.5 to 2 liters per day. If averse symptoms arise then hydration may be have to be added intravenously.

I think the biggest issue to patients getting access to this drug, is that the reported cost of the drug is approx $100,000 US per year.

Speak with your Oncologist or other Cancer Secialist, about Venclexta (Venetoclax), if you have diagnosed with Chronic Lymphocytic Leukemia (CLL).

Click on this Link to Download the FDA Fact Sheets PDF for Venclexta (Venetoclax).

Click on this Link which details the FDA Approval of Venclexta (Venetoclax).

Click on this Link to visit the official Venclexta (Venetoclax) website.

Click on this Link to visit the Drugs.com website to read their detailed pages about Venclexta (Venetoclax).

Click on this line to visit the The Genentech® Access to Care Foundation to see if you may qualify to get help the High Cost of being treated with Venclexta (Venetoclax). If you qualify, you may get Venclexta (Venetoclax) at no cost to you.

 

Posted by: Vincent Banial
http://www.uniquelytoronto.com

Disclaimer: Any Trademarks mentioned in this post are owned by the respective Trademark owner. There could be unintentional errors or omissions in this post. Always refer to the official sites to confirm details and any ongoing changes or updates. This post is subject to change without notice. Any offers mentioned in this post are also subject to change without notice.

Researchers found that those who took acetaminophen showed a reduction in empathy.

A new Research Study out of The Ohio State University found that those who took acetaminophen showed a reduction in empathy. They weren’t as concerned about another person’s person’s hurt feelings. The Study was published on May 05 2016 in the journal “Social Congitive and Affective Neuroscience, which is one of the Oxford Journals.

Video is courtesy of the Fox Business YouTube channel

Acetaminophen is the main ingredient in the over the counter pain relief medication called Tylenol.

 

The authors of the study were:

Baldwin Way

Dominik Mischkowski

and Jennifer Crocker

 

Click on this line to visit the Oxford Journals site to view the Study Abstract
From Painkiller to Empathy Killer: Acetaminophen (Paracetamol) Reduces Empathy for Pain

 

Posted by: Vincent Banial
http://www.uniquelytoronto.com

Disclaimer: Any Trademarks mentioned in this post are owned by the respective Trademark owner. There could be unintentional errors or omissions in this post. Always refer to the official sites to confirm details and any ongoing changes or updates. This post is subject to change without notice.

Northwestern researchers have discovered that when the human egg is activated by a sperm enzyme, an explosion of zinc sparks erupt


Northwestern University researchers have discovered that when the human egg is activated by a sperm enzyme, an explosion of zinc sparks erupt

If the videos do not start automatically, then click on the two  links below. They are from the study published in Scientific Reports

http://www.nature.com/article-assets/npg/srep/2016/160426/srep24737/extref/srep24737-s1.avi

http://www.nature.com/article-assets/npg/srep/2016/160426/srep24737/extref/srep24737-s2.avi

Video is courtesy of GeoBeats News YouTube channel

Abstract

Egg activation refers to events required for transition of a gamete into an embryo, including establishment of the polyspermy block, completion of meiosis, entry into mitosis, selective recruitment and degradation of maternal mRNA, and pronuclear development. Here we show that zinc fluxes accompany human egg activation. We monitored calcium and zinc dynamics in individual human eggs using selective fluorophores following activation with calcium-ionomycin, ionomycin, or hPLCζ cRNA microinjection. These egg activation methods, as expected, induced rises in intracellular calcium levels and also triggered the coordinated release of zinc into the extracellular space in a prominent “zinc spark.” The ability of the gamete to mount a zinc spark response was meiotic-stage dependent. Moreover, chelation of intracellular zinc alone was sufficient to induce cell cycle resumption and transition of a meiotic cell into a mitotic one. Together, these results demonstrate critical functions for zinc dynamics and establish the zinc spark as an extracellular marker of early human development.

Click on this line to visit the Northwestern University website page where this research is discussed.

Click on this line to visit the Scientific Reports website to read the complete study titled:

The zinc spark is an inorganic signature of human egg activation

Please note that there is download link at the above linked to Scientific Reports site, which allows you to download the full study report.

Title:
The zinc spark is an inorganic signature of human egg activation

Authors: Francesca E. Duncan, Emily L. Que, Nan Zhang, Eve C. Feinberg, Thomas V. O’Halloran et al.

Publication: Scientific Reports

Publisher: Nature Publishing Group

Date: Apr 26, 2016

Copyright © 2016, Rights Managed by Nature Publishing Group

Creative Commons

The article for which you have requested permission has been distributed under a Creative Commons CC-BY license (please see the article itself for the license version number). You may reuse this material without obtaining permission from Nature Publishing Group, providing that the author and the original source of publication are fully acknowledged, as per the terms of the license.
For license terms, please see http://creativecommons.org/

 

Posted by: Vincent Banial
http://www.uniquelytoronto.com

Disclaimer: Any Trademarks mentioned in this post are owned by the respective Trademark owner.

If the Cancerous Tumor can be reached by thin optic fibers then this minimally invasive procedure could be an effective way to treat said Tumor

Getting any form of cancer can be life changing. The medical procedures used to eliminate the Cancer can also have life changing side effects.

Removing a Cancerous Prostate is one present way to deal with Colon Cancer.

There is a novel new procedure which has already been approved for use in Mexico. It may soon be approved for use in Europe.

The key part is that the procedure is minimally invasive. If the Cancerous Tumor can be reached by thin optic fibers then this procedure could be an effective way to treat said Tumor. The thin optic fiber is needed to direct the Laser light at the Tumor. “Laser light activation of an intravenous infusion of Tookad Soluble releases short-lived toxic oxygen and nitric oxide radicals that destroy the Cancer tumor’s blood vessels and thereby kill the tumorous cells”. The Tookad Soluble drug is eliminated from the body in less than 6 hours. Without the Laser Light activation the Tookad Soluble has no effect on other cells or organ. Ultra Sound is used to feed and direct the Optic Fibres into the patients body.

This new technology was developed by the Yeda Research and Development Company, of the Weizmann Institute in collaboration with Steba Biotech of Luxembourg. Steba Biotech received the license for Tookad Soluble from Yeda Research and Development Company.

Since this procedure can target Cancer Tumors where a Fibre Optic strand could reach the tumor, then the door may be open to treat many other forms of Cancer. More research and Clinical Studies are underway.

Click on this line to read much more detail about using Tookad Soluble activation via Laser Light to target Cancer Tumors.

Click on this line to visit the Times Of Israel news website to read their article on this procedure first developed by the Weizmann Institute.

 

 

Posted by: Vincent Banial
http://www.uniquelytoronto.com

Disclaimer: Any Trademarks mentioned in this post are owned by the respective Trademark owner. There could be unintentional errors or omissions in this post. Always refer to the official sites to confirm details and any ongoing changes or updates. This post is subject to change without notice.

Scanning ultrasound removes amyloid-β and restores memory in an Alzheimer’s disease mouse model

I used to post about Medical Research in the past. For example, our prior post about research done at Harvard regarding the association between Heart Disease and microbial Human Gut Bacteria had researchers from around the globe visiting this site. Hey life is not just about great looking Exotic Cars, great looking Women and great sounding Music. You should add Medical Research to “round out” that mix.

This post is about research being conducted in Australia, which shows great promise in the treatment of Alzheimers. Apparently some memory loss could be reversed, in mice so far, by using their protocol and Scanning UltraSound.

The study was conducted by : Gerhard Leinenga and Jürgen Götz. Corresponding author. E-mail: j.goetz@uq.edu.au

Their study was published in the peer reviewed journal: Science Translational Medicine 11 Mar 2015: Vol. 7, Issue 278

The article was titled: Research Article Alzheimer’s Disease
Scanning ultrasound removes amyloid-β and restores memory in an Alzheimer’s disease mouse model.

The following is the Abstract (posted for Educational purposes). A link is provided further down to access the complete text and a downloadable PDF.

Abstract

Amyloid-β (Aβ) peptide has been implicated in the pathogenesis of Alzheimer’s disease (AD). We present a nonpharmacological approach for removing Aβ and restoring memory function in a mouse model of AD in which Aβ is deposited in the brain. We used repeated scanning ultrasound (SUS) treatments of the mouse brain to remove Aβ, without the need for any additional therapeutic agent such as anti-Aβ antibody. Spinning disk confocal microscopy and high-resolution three-dimensional reconstruction revealed extensive internalization of Aβ into the lysosomes of activated microglia in mouse brains subjected to SUS, with no concomitant increase observed in the number of microglia. Plaque burden was reduced in SUS-treated AD mice compared to sham-treated animals, and cleared plaques were observed in 75% of SUS-treated mice. Treated AD mice also displayed improved performance on three memory tasks: the Y-maze, the novel object recognition test, and the active place avoidance task. Our findings suggest that repeated SUS is useful for removing Aβ in the mouse brain without causing overt damage, and should be explored further as a noninvasive method with therapeutic potential in AD.

Click on this line to view the complete text regarding the published results of this study.

Click on this line to view the entire article as a PDF or to Download a PDF copy of the Published material courtesy of the Science Translational Medicine site.

Click on this line to visit the official website of the Queensland Brain Institute at The University of Queensland Australia

Click on this line to visit the Clem Jones Centre for Ageing Dementia Research (CJCADR)

 

 

Posted by: Vincent Banial
http://www.uniquelytoronto.com

Disclaimer: Any Trademarks mentioned in this post are owned by the respective Trademark owner. There could be unintentional errors or omissions in this post. Always refer to the official sites to confirm details and any ongoing changes or updates. This post is subject to change without notice. The Study Abstract has been included in this post for Educational Purposes and so is covered by the Fair Use component of Copyright. Uniquely Toronto makes no claims regarding the copyright or other rights to the published material. Also complete links have been included to the Science Translational Medicine site.

The Truth About Cancer: A Global Quest docu-series – official trailer

Video is courtesy of The Truth About Cancer YouTube channel

 

 

Posted by: Vincent Banial
http://www.uniquelytoronto.com

Disclaimer: Any Trademarks mentioned in this post are owned by the respective Trademark owner.

Fasting may have postive effects on Human Brains. This Ted Talk is presented by Neuroscientist Mark Mattson

A very interesting Ted Talk about the positive effects of fasting on the Brain. It is presented by Mark Mattson is the current Chief of the Laboratory of Neurosciences at the National Institute on Aging.

Video is courtesy of the TEDx Talks YouTube channel

From the research which Mark Mattson is undertaking, Fasting could benefit those suffering with Alzheimer’s Disease & Dementia.

As the number of Alzheimer’s Disease & Dementia patients spiral upwards, the research on Fasting could prove most important.

Posted by: Vincent Banial
www.uniquelytoronto.com

Disclaimer: Any Trademarks mentioned in this post are owned by the respective Trademark owner.

New Contagious form of Cancer discovered

Click n the link below to read the article posted on the Business Standard website, about a new Contagious for of Cancer which has been discovered.

http://mybs.in/2S2uNPj

Cancer is “very rarely” contagious. I believe that there exist only about 2 or 3 forms of cancer, which can survive the move from the original Host body to the Next Host body.

Posted by: Vincent Banial
www.uniquelytoronto.com

Disclaimer: Any Trademarks mentioned in this post are owned by the respective Trademark owner. There could be unintentional errors or omissions in this post. Always refer to the official sites to confirm details and any ongoing changes or updates. This post is subject to change without notice. Posting links is covered under the Fair Use Provision of Copyright. Permission was also granted by the Business Standard site to share their post link.

New Medical Study just published in the journal Cell: Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis

TMAlyase_GUT_graphical abstract_HAZEN-3Image is courtesy of the journal Cell which retains the Copyright and any and all other rights. Used with permission for educational purpose.

A new study just published in the peer reviewed journal Cell goes further into the research which we had posted about on Apil 08 2013. That 2013 post was titled : Intestinal microbiota metabolism producing Trimethylamine-N-Oxide (TMAO), may be a contributing factor in developing Cardiovascular Disease in Humans. That was an extremely important study which had been published in the peer reviewed journal Nature Medicine. Click on the previous line to read about that extremely important finding, as I believe that it presents a new foundation upon which we can potentially reverse Cardiovascular Disease in Humans.

The following are quotes about the new study from the journal Cell which was titled:
Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis

Highlights

•Gut microbial trimethylamine lyases are a therapeutic target for atherosclerosis
•3,3-dimethyl-1-butanol inhibits microbial trimethylamine formation
•3,3-dimethyl-1-butanol attenuates choline diet-enhanced atherosclerosis
•Non-lethal gut microbial enzyme inhibition can impact host cardiometabolic phenotypes

Summary

Trimethylamine (TMA) N-oxide (TMAO), a gut-microbiota-dependent metabolite, both enhances atherosclerosis in animal models and is associated with cardiovascular risks in clinical studies. Here, we investigate the impact of targeted inhibition of the first step in TMAO generation, commensal microbial TMA production, on diet-induced atherosclerosis. A structural analog of choline, 3,3-dimethyl-1-butanol (DMB), is shown to non-lethally inhibit TMA formation from cultured microbes, to inhibit distinct microbial TMA lyases, and to both inhibit TMA production from physiologic polymicrobial cultures (e.g., intestinal contents, human feces) and reduce TMAO levels in mice fed a high-choline or L-carnitine diet. DMB inhibited choline diet-enhanced endogenous macrophage foam cell formation and atherosclerotic lesion development in apolipoprotein e−/− mice without alterations in circulating cholesterol levels. The present studies suggest that targeting gut microbial production of TMA specifically and non-lethal microbial inhibitors in general may serve as a potential therapeutic approach for the treatment of cardiometabolic diseases.”

The authors and researchers of this new Study were:
Zeneng Wang, Adam B. Roberts, Jennifer A. Buffa, Bruce S. Levison, Weifei Zhu, Elin Org, Xiaodong Gu, Ying Huang, Maryam Zamanian-Daryoush, Miranda K. Culley, Anthony J. DiDonato, Xiaoming Fu, Jennie E. Hazen, Daniel Krajcik, Joseph A. DiDonato, Aldons J. Lusis and Stanley L. Hazen

Click on this line to visit the journal Cell website, which features the Full Text of this important newly published Study.

Click on this line to download the PDF of this new Study, from the Journal Cell’s website.

In laymen’s terms, this new Study (published in the journal Cell, showed that by lnhibiting the production of TMAO during the digestion process, clogging of arteries was vastly reduced in Mice. What worked in Mice could work in a similar manner in Humans. This study, in my opinion, adds a new layer to the very important knowledge foundation which was laid with the initial work published in the journal Nature Medicine (click here to view that post)

 

 

Posted by: Vincent Banial
http://www.uniquelytoronto.com

Disclaimer: Any Trademarks mentioned in this post are owned by the respective Trademark owner. There could be unintentional errors or omissions in this post. Always refer to the official sites to confirm details and any ongoing changes or updates. This post is subject to change without notice. Neither Vincent Banial nor Uniquely Toronto make any claims to the copyright to the material discussed in the above post. Copyright is retained by the authors of the study and with the journal Cell.

This post is not meant to be medical advice. Always seek the help and advice of your on Medial Doctor. This post is strictly for “Educational Purposes”. Our initial post about TMAO (posted on April 08 2013 is one of our most popular posts. Students and researches from all around the globe have visited our site just to read that educational post.

Knowledge is power and I strive to give back to humanity, by posting information for educational purposes, such as this post.

This post is also licensed to share under the Creative Commons License

Attribution-NoDerivs
CC BY-ND

This license allows for redistribution, commercial and non-commercial, as long as it is passed along unchanged and in whole, with Credit and Attribution to Vincent Banial.

The University of Iowa medical study finds Diet Drink consumption may be associated with heart trouble for older women

I know, I know that I said that I won’t be posting here for a while. I’ll likely have withdrawal symptoms this weekend <grin>.

I just ran across the results from a large medical study which looked at Diet Drink consumption and cardiovascular health in almost 60,000 women. The University of Iowa medical study found Diet Drink consumption may be associated with heart trouble for older women and I felt that it was important enough to take some time and post a link to it.

Click on the following link to read more details from The University of Iowa :

http://now.uiowa.edu/2014/03/ui-study-finds-diet-drinks-associated-heart-trouble-older-women

Posted by: Vincent Banial for Uniquely Toronto
http://www.uniquelytoronto.com

Disclaimer: Any Trademarks mentioned in this post are owned by the respective Trademark owner. There could be unintentional errors or omissions in this post. Always refer to the official sites to confirm details and any ongoing changes or updates. This post is subject to change without notice.

An Aspirin a day could double survival chances of cancer sufferers

http://www.express.co.uk/life-style/health/608395/Cancer-survival-aspirin-a-day-pill-breast-heart-disease-Alzheimer-s-disease

Posted by: Vincent Banial for Uniquely Toronto
http://www.uniquelytoronto.com

Disclaimer: Any Trademarks mentioned in this post are owned by the respective Trademark owner. There could be unintentional errors or omissions in this post. Always refer to the official sites to confirm details and any ongoing changes or updates. This post is subject to change without notice.

Brain implant could reverse memory loss in Alzheimers patients

http://www.express.co.uk/news/uk/609875/new-implant-reverse-Alzheimers-memory-loss-high-tech-device-treatment

Posted by: Vincent Banial for Uniquely Toronto
http://www.uniquelytoronto.com

Disclaimer: Any Trademarks mentioned in this post are owned by the respective Trademark owner. There could be unintentional errors or omissions in this post. This post is subject to change without notice.

Neuroscientist Sara Lazar’s amazing brain scans show meditation can actually change the size of key regions of our brain, improving our memory and making us more empathetic, compassionate, and resilient under stress.

Video is courtesy of the TEDx Talks YouTube page

 

 

Posted by: Vincent Banial for Uniquely Toronto
http://www.uniquelytoronto.com

Disclaimer: Any Trademarks mentioned in this post are owned by the respective Trademark owner. There could be unintentional errors or omissions in this post. Always refer to the official sites to confirm details and any ongoing changes or updates. This post is subject to change without notice.

Susan Cain discusses her book titled “Quiet. The Power of Introverts”

Introverts can be found in Human populations, in Animal populations and among Fish.

Susan Cain details some the extensive research about the differences between Human Extroverts and Human Introverts.

This fascinating video is thanks to Microsoft Research, which is the research division of Microsoft.

Video is courtesy of the UWTV YouTube Channel and Microsoft Research

Posted by: Vincent Banial for Uniquely Toronto
http://www.uniquelytoronto.com

Disclaimer: Any Trademarks mentioned in this post are owned by the respective Trademark owner. There could be unintentional errors or omissions in this post. This post is subject to change without notice.