Category: Research Studies
New Medical Study sheds light on P. gingivalis colonization in a Human Brain as being the cause of developing Alzheimer’s Disease. The study also found that 100% of patients with Cardiovascular Disease had P. gingivalis arterial colonization.
Having Bad Breath could be a Major Risk Factor in developing Alzheimer’s Disease and Cardiovascular Disease.
A new Medical Study just released sheds light on P. gingivalis colonization in a human Brain as being the cause of developing Alzheimer’s Disease. The study also found that 100% of patients with Cardiovascular Disease had P. gingivalis arterial colonization.
The medical study is published by American Association for the Advancement of Science – Science Advances. Click on this link to visit the Science Advances site to read the study titled “Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors“.
The following are brief excerpts (you can read the full Study at the link noted above) from this new Research Study:
“The bacterium called gingipains (P. gingivalis) were identified in the brain of Alzheimer’s patients.”
Video is courtesy of OSH News Network YouTube Channel
“Oral P. gingivalis infection in mice resulted in brain colonization and increased production of Aβ1–42, a component of amyloid plaques. Further, gingipains were neurotoxic in vivo and in vitro, exerting detrimental effects on tau, a protein needed for normal neuronal function.”
“Alzheimer’s disease (AD) patients exhibit neuroinflammation consistent with infection, including microglial activation, inflammasome activation, complement activation, and altered cytokine profiles (1, 2). Infectious agents have been found in the brain and postulated to be involved with AD, but robust evidence of causation has not been established (3).”
“In Apoe−/− mice, oral infection with P. gingivalis, but not with two other oral bacteria, results in brain infection and activation of the complement pathway (14). In transgenic mice overexpressing mutated human amyloid precursor protein (hAPP-J20), oral infection with P. gingivalis impairs cognitive function, increases the deposition of AD-like plaques, and results in alveolar bone loss compared to control hAPP-J20 mice (15). P. gingivalis lipopolysaccharide has been detected in human AD brains (16), promoting the hypothesis that P. gingivalis infection of the brain plays a role in AD pathogenesis (17).”
“P. gingivalis is mainly found during gingival and periodontal infections; however, it can also be found at low levels in 25% of healthy individuals with no oral disease (18). Transient bacteremia of P. gingivalis can occur during common activities such as brushing, flossing, and chewing, as well as during dental procedures (19), resulting in documented translocation to a variety of tissues including coronary arteries (20), placenta (21), and liver (22).”
“A recent study found that 100% of patients with cardiovascular disease had P. gingivalis arterial colonization.” (23).
Video is courtesy of John Douillard YouTube Channel
Click on this link to visit the New Scientist website to reqd their article titled “We may finally know what causes Alzheimer’s – and how to stop it“.
Posted by: Vincent Banial
Pirate Queen of Academic Research Papers
Really insightful article about about who owns academic research online.
Over half of all research, according to one study, is now published by the big five of academic publishing. To view research papers one has to go thru a paywall and pay for access to each research paper.
Most academic research is funded by Governmental Agencies. So the Taxed payers pay for the research to be done. Ask yourself this question: Since Tax Payer money funded the Academic Research, then should all resulting research papers be available to read for free?”
Video is courtesy of the Life Extension Advocacy Foundation YouTube Channel
Unfortunately at present if you want to view the results and read the published research papers one has to pay the private publishers via website Paywalls to access the research papers.
A new alternative has appeared, that being Open Access: “free availability on the public internet,” Click on this line to visit PLOS ONE – an Open Access site
This really good article is about Alexandra Elbakyan, a gifted programmer, who setup Sci-Hub – a site where one can download research papers for free.
The major publishers of Academic Research papers make a fortune and see Open Access and Alexandra’s Sci-Hub as cutting into their profits and ability to Hoard ever More Money by raising prices. So they have sued Alexandra Elbakyan. The lawsuits have impacted Internet Service providers and some believe hinder a free and open Internet.
Click on this line to the visit The Verge website to read their article titled:
“Science’s Pirate Queen”.
THC inhibits growth and metastasis of Lung Cancer, per Research Study at the Beth Israel Deaconess Medical Center – Harvard University
Back in 2007, the American Association for Cancer Research published Information about research which was presented at their annual meeting by
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Beth Israel Deaconess Medical Center – Harvard University
BIDMC, Harvard University, Boston, MA
Click on this link to visit the Cancer Research Journal webpage titled: Tetrahydrocannabinol inhibits growth and metastasis of lung cancer.
The closing important paragraph from the Abstract published by the Cancer Research Journal is below:
Cumulatively, these studies indicate that THC has anti-tumorigenic and anti-metastatic effects against lung cancer. Novel therapies against EGFR overexpressing, aggressive and chemotherapy resistant lung cancers may include targeting the cannabinoids receptors.
Posted by: Vincent Banial
The FDA approved Epidiolex (cannabidiol) [CBD] oral solution for the treatment of seizures associated with two rare and severe forms of epilepsy, Lennox-Gastaut syndrome and Dravet syndrome, in patients two years of age and older.
Click on this link to read the Official US Food & Drug Administration Press Release :
FDA approves first drug comprised of an active ingredient derived from marijuana to treat rare, severe forms of epilepsy
The video is courtesy of the All News YouTube channel
Click on this link to visit the New Scientist website to read their post titled: “First cannabis-based drug approved in the US to treat epilepsy”.
Click on this link to read about GW Pharmaceuticals plc Epidiolex development
Matthew Walker discusses the latest discoveries why we sleep and how sleep impacts your life.
Professor Matthew Walker PhD, Director of UC Berkeley’s Sleep and Neuroimaging Lab discusses the latest discoveries about sleep and how it impacts our life, wellness, and lifespan.
Video is courtesy of the Talks at Google YouTube channel.
Click on this Link to visit Amazon.com to purchase Mathew Walker’s best selling book tilted: “Why We Sleep: Unlocking the Power of Sleep and Dreams“.
PSA Testing for Prostate Cancer made No Significant Difference in Prostate Cancer Deaths after 10 years.
A new study has been published Mar 06 2018, in the Peer-Reviewed Medical Journal called Journal of the American Medical Association (or JAMA). The Study found that PSA test screening did not achieve its aim of diagnosing fast-growing cancers in time to treat them and prevent Deaths.
Video is courtesy of the University of Bristol YouTube Channel
Title: Effect of a Low-Intensity PSA-Based Screening Intervention on Prostate Cancer Mortality: The CAP Randomized Clinical Trial
Author: Martin, Richard M.; Donovan, Jenny L.
Publication: JAMA
Publisher: American Medical Association
Date: Mar 6, 2018
There were men who were tested and the PSA Test found that they had a High PSA. Of those who agreed to further treatment during the study, some men were seriously harmed by treatment. There were 8 deaths in the screening group related to either the biopsy or prostate cancer treatment and 7 in the control group.
Click on this Link to the study published In JAMA on on Mar 06 2018 and titled “Effect of a Low-Intensity PSA-Based Screening Intervention on Prostate Cancer MortalityThe CAP Randomized Clinical Trial“.
Click on this link to visit the JAMA website and listen to an MP3 of the highlights of the Mar 06 2018 issue of the Journal of the American Medical Association.
Click on this Link to visit the Cancer Research UK website to read their post titled: “Why a one-off PSA test for prostate cancer is doing men more harm than good“
Click on this link to visit The Telegraph newspaper website to read their article titled “Prostate screening saves no lives and may do more harm than good“.
How injecting THC and injecting Placebo into veins causes Paranoia, per the results of a poorly designed Oxford University Research Study
Oxford University had posted a News Post titled : “How cannabis causes paranoia”.
Clearly a poorly designed study or one designed to give a negative impression of Cannabis. The study was not about the normal use of Cannabis. It was a study where participants were injected with THC. In the Real World, no one does that.
First of all, they injected THC directly into the veins of participants. IN the Real World, Cannabis users “Do Not” consume Cannabis in that manner. They were only testing THC and not Cannabis. THC is a chemical found in Cannabis, but there are also other chemicals in the Cannabis Plant.
When you smoke or eat Cannabis, it takes time to consume the Joint or Muffin. It takes time for the THC (and other chemicals) to get into the bloodstream. The brain is slowly affected.
When you inject THC, (which “no one” does in the real world) your brain gets hit by the psychoactive chemical THC all at once. There are other Cannabinoids and other chemicals in Cannabis when smoked or eaten. Those other chemicals work with the THC. This test does not represent Cannabis. It represents Injecting THC.
Clearly this was a poorly designed Research Study.
I have never heard of people becoming Paranoid after smoking a joint. Getting the Giggles and laughing at stupid stuff – yes. Getting the Munchies and having a group order Pizza to be delivered – yes. Paranoia – nada.
A clear example is concerts. If you step off to the sidelines and look up you will see a haze of smoke rising from the audience. They are smoking Cannabis – it also has a specific fragrance. I remember Maple Leaf Gardens – same thing rising above the Audience. If large numbers of people were all experiencing Paranoia, they would be running for the exits (or at least a large number would). That has never happened. I have attended and photographed a heck of a lot of concerts and have never seen a mass exit of the audience after they smoked their Cannabis. They all seemed to dance and have fun and enjoyed the music.
Coachella, A recent outdoor concert in the California had an area where free Cannabis was available (to eat and smoke) to those with VIP tickets. Not one single person ran out of that area, because the Cannabis supposedly, as per the failed Oxford study, caused Paranoia.
The other rather interesting thing about that Oxford study is that 30% of the Placebo group “also experienced Paranoia” after being injected with Placebo.
Seems to me that participants lacked Trust in what was being injected into their arms. 50% of those injected with THC experienced Paranoid thoughts. 30% of the participants who were injected with a Placebo also experienced Paranoid thoughts. This is not a normal type of result for a Placebo Group. Interesting how the report of the study did not go into why the 30% of those injected with Placebo had experienced Paranoid thoughts…
I’ll give an example to clarify. Say you wanted to do a study of the effects of drinking two glasses of Red Cabernet Wine each day with your supper. Clearly injecting the equivalent amount of alcohol found in two glasses of Red Wine (12% Alcohol by volume) directly into study participants veins would have a totally different effect than drinking two glasses of wine with supper. No one would design such a sham of study and proclaim the results show the negative effect of drinking two glasses of Red Wine with your supper. Yet this is what was done in the above noted Oxford Study. They injected THC and their News Post was then titled “How Cannabis Causes Paranoia”. They only tested THC (the psychoactive cannabinoid found in Cannabis). They “did not test” using Cannabis. The THC was injected directly into the bloodstream of the participants. No Cannabis was ingested or smoked by the participant. Actually “no Cannabis was ever used” by the Oxford study participants.
That study was funded by the National Health Dept. Medical use of Cannabis is banned by the National Dept of Health. If one wants future Research Funding, does one rock the boat?
Click on this link to visit the University of Oxford website to read their News post titled “How Cannabis Causes Paranoia”.
Here is the URL incase the link has issues: http://www.ox.ac.uk/news/2014-07-16-how-cannabis-causes-paranoia
They could also have called the article
“How injecting Placebo causes Paranoia.“
Posted by Vincent Banial
Metabolically starving Cancer Cells through diet and compressed oxygen, replacing chemotherapy, surgery, or radiation is a therapy developed by Dr. Dominic D’Agostino
Dr. Dominic D’Agostino is an Assistant Professor at the University of South Florida College Of Medicine, Molecular Pharmacology & Physiology where he develops and tests Metabolic Therapies, including alternative energy substrates and ketogenic agents for neurological disorders, Cancer and wound healing.
While studying the effects of gasses on the brains of Navy Seal divers, he developed an approach for metabolically starving Cancer Cells through diet and compressed oxygen, replacing chemotherapy, surgery, or radiation.
Video is courtesy of the TEDx Talks YouTube channel
Click on this link to visit the official site of Dr. Dominic D’Agostino.
Posted by Vincent Banial
New Research at Salk Institute shows that Cannabinoids remove plaque-forming Alzheimer’s proteins from brain cells
Medical Cannabis could possibly halt Alzheimer’s and could maybe even reverse the damage caused by Alzheimer’s. That is my interpretation of the results from a medical study conducted by Salk Institute Scientists.
The following is from their News Release:
“Salk Institute scientists have found preliminary evidence that tetrahydrocannabinol (THC) and other compounds found in marijuana can promote the cellular removal of amyloid beta, a toxic protein associated with Alzheimer’s disease.”
“Although other studies have offered evidence that cannabinoids might be neuroprotective against the symptoms of Alzheimer’s, we believe our study is the first to demonstrate that cannabinoids affect both inflammation and amyloid beta accumulation in nerve cells,” says Salk Professor David Schubert, the senior author of the paper.”
I am not giving any medical Advice with the following statements. Maybe discuss with the Medical Doctor taking care of a family member suffering from Alzheimer’s. Ask the Doctor for a prescription for Medical Cannabis, which is available in Canada and many states in America. Working with their Medical Doctor, one could maybe create your own private human trial under your Doctor’s supervision. In my mind, the risk is extremely low. Keep notes and search the internet for Cogniition Tests (Alzheimer’s Associations are a good resource) . Under the care of a Medical Doctor, testing to see if Medical Cannabis could reduce the effects of Alzheimer’s and improve cognition, in my opinion, has a high safety factor. For example, no one has died from smoking or eating too much Cannabis. On the other hand, thousands of people have died due to major Liver damage caused by overdosing on medication such as Tylenol.
Click on the following link to read the News Release about the new finding from the Salk Institute website.
Click on this link to visit the Journal Aging and Mechanisms of Disease to read the published Salk Institute Study titled : “Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids“
| Title: | Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids |
| Author: | Antonio Currais, Oswald Quehenberger, Aaron M Armando, Daniel Daugherty, Pam Maher et al. |
| Publication: | npj Aging and Mechanisms of Disease |
| Publisher: | Nature Publishing Group |
| Date: | Jun 23, 2016 |
| Copyright © 2016, Rights Managed by Nature Publishing Group | |
Click on this link to download a PDF copy of the study from the site of the Journal
New Medical Study: “Creating beauty: Creativity compensates for low physical attractiveness when individuals assess the attractiveness of social and romantic partners” by Christopher D. Watkins
If you are a lucky male who was born incredibly handsome, you may want to skip this discussion of a new Scientific Study. On the other hand, if you are an average or below average looking male, this new Study titled: “Creating beauty: Creativity compensates for low physical attractiveness when individuals assess the attractiveness of social and romantic partners” by
I run this blog and shoot photographs of events such as shows and concerts. I do it for the fun of it. Today I learned that there are other benefits to being “creative” and displaying your creativity. My creativity will compensate for my “not being” a total male hunk and Eye Candy in a woman’s eyes. That’s not to say that I’m ugly, just average looking. Ask any guy if they would prefer a beautiful girlfriend or one which looks just average. Surprise, the same goes for women. Humans prefer beauty in their partners. It is instinctive and meant to help continue with the survival of the human species.
This newly published Research Study conducted by Christopher Watkins of Abertay University in Scotland helps to explain some of the extremely gorgeous women that I have dated in my life. The downside of dating a really great looking woman is that any other guys in the same room will be doing body scans of your girlfriend.
So how is that a physically gorgeous female super model would even go out with an average looking guy like me?
Unfortunately, this does not apply to women. Displays of creativity by an average looking women, will not enhance her appeal to the eyes of a male. Us males are rather fixated on physical beauty. Your average looking female can have tons of “inner beauty” and in the end that is far more important. But males generally look at the outer packaging.
Enough of Vince’s banter, I know that the readers here can’t wait to view this new Research Study, which is below. Please note that I am posting this new research with permission, but that does not mean that
Abstract
Although creativity is attractive in a potential mate, it is unclear (i) whether the effects of creativity on attractiveness generalize to other social contexts and (ii) whether creativity has equivalent effects on men’s and women’s attractiveness. As social knowledge of creativity may either enhance or ‘offset’ the appeal of social partners who differ in physical attractiveness, three repeated measures experiments were conducted to directly address these issues. Here, participants rated a series of face–text pairs for attractiveness on trials that differed in one of four combinations of facial attractiveness (attractive and less attractive) and creativity (creative and less creative), rating story-tellers in two experiments (short interpretations of an identical painting) and creative ideas in a further experiment (alternative uses for an everyday object). Regardless of the sex of the judge, creativity and facial attractiveness had independent effects on men’s overall attractiveness (initial experiment) and, in further experiments, more substantial effects on the attractiveness of men with less attractive faces than men with attractive faces (when using a different measure of creativity) and specific effects on the attractiveness of individuals with less attractive faces (when using different face stimuli). Collectively, across three experiments, these findings suggest that creativity may compensate for putative cues to lower biological ‘quality’ and that the benefits of creativity to social groups more generally enhance attraction to creative men (in two experiments) and creative men and women (one experiment). More broadly, the data suggest that species can integrate knowledge of cognitive intelligence with visual cues to biological ‘quality’ to facilitate mate and/or ally choice.
John Goodenough and Maria Braga research on a New Solid State Battery design which stores 3x the power of a similar sized Lithium Ion battery and will charge in minutes
Posted by Vincent Banial
John Goodenough helped to develop the Lithium-Ion Battery. He and Maria Helena Braga are part of a team, which has designed a New Technology for High capacity, Fast-Charging and Noncombustible Batteries.
Such a battery could let one drive an electric car for up to 500 miles or more between battery charges. The battery could charge in the time it takes to order and eat a sandwich while drinking a cup of coffee at a roadside restaurant. The key safety feature is that the new battery design would not burst into flames if the battery is punctured
Photo of John Goodenough courtesy of UTNews The University of Texas at Austin
The research paper titled “Alternative strategy for a safe rechargeable battery” by Energy & Environmental Science”
Uniquely Toronto 