Tagged: Medical Research

“Making Peace with Cannabis” by Zach Walsh, PhD, Assistant Professor in the UBC Department of Psychology

This TEDx Talk is titled “Making Peace with Cannabis“. It features Zach Walsh, PhD, who is an Assistant Professor in the UBC Department of Psychology and Co-Director for the Centre for the Advancement of Psychological Science and Law. He is also involved in a current study at UBC which is investigating treating PTSD using Medical Cannabis.

Video is courtesy of the TEDx Talks YouTube channel

Black Pepper Oil inhibited Cancer Cells proliferation by 3.5-86.8%.

Posted by Vincent Banial

The Medical Research Study was conducted by Bioactive Natural Products and Phytoceuticals, Department of Horticulture and National Food Safety and Toxicology Center, Michigan State University, East Lansing, Michigan 48824, USA. The results were authored by Liu Y1, Yadev VR, Aggarwal BB, Nair MG.

Study “results suggest that black pepper and its constituents like hot pepper, exhibit anti-inflammatory, antioxidant and anticancer activities“.

The extracts of black pepper at 200 microg/mL and its compounds at 25 microg/mL inhibited LPO by 45-85%, COX enzymes by 31-80% and cancer cells proliferation by 3.5-86.8%.

Abstract

“Black pepper (Piper nigrum) and hot pepper (Capsicum spp.) are widely used in traditional medicines. Although hot Capsicum spp. extracts and its active principles, capsaicinoids, have been linked with anticancer and anti-inflammatory activities, whether black pepper and its active principle exhibit similar activities is not known. In this study, we have evaluated the antioxidant, anti-inflammatory and anticancer activities of extracts and compounds from black pepper by using proinflammatory transcription factor NF-kappaB, COX-1 and -2 enzymes, human tumor cell proliferation and lipid peroxidation (LPO). The capsaicinoids, the alkylamides, isolated from the hot pepper Scotch Bonnet were also used to compare the bioactivities of alkylamides and piperine from black pepper. All compounds derived from black pepper suppressed TNF-induced NF-kappaB activation, but alkyl amides, compound 4 from black pepper and 5 from hot pepper, were most effective. The human cancer cell proliferation inhibitory activities of piperine and alklyl amides in Capsicum and black pepper were dose dependant. The inhibitory concentrations 50% (IC50) of the alklylamides were in the range 13-200 microg/mL. The extracts of black pepper at 200 microg/mL and its compounds at 25 microg/mL inhibited LPO by 45-85%, COX enzymes by 31-80% and cancer cells proliferation by 3.5-86.8%. Overall, these results suggest that black pepper and its constituents like hot pepper, exhibit anti-inflammatory, antioxidant and anticancer activities.”.

Click on this line to visit the US National Library of Medicine National Institutes of Health PubMed site to read about this research titled “Inhibitory effects of black pepper (Piper nigrum) extracts and compounds on human tumor cell proliferation, cyclooxygenase enzymes, lipid peroxidation and nuclear transcription factor-kappa-B.

New Medical Study: “Creating beauty: Creativity compensates for low physical attractiveness when individuals assess the attractiveness of social and romantic partners” by Christopher D. Watkins

If you are a lucky male who was born incredibly handsome, you may want to skip this discussion of a new Scientific Study. On the other hand, if you are an average or below average looking male, this new Study titled: “Creating beauty: Creativity compensates for low physical attractiveness when individuals assess the attractiveness of social and romantic partners” by Christopher D. Watkins of Abertay University in Scotland may just help shed light on ways to improve your romantic life or maybe even get one.

I run this blog and shoot photographs of events such as shows and concerts. I do it for the fun of it. Today I learned that there are other benefits to being “creative” and displaying your creativity. My creativity will compensate for my “not being” a total male hunk and  Eye Candy in a woman’s eyes.  That’s not to say that I’m ugly, just average looking. Ask any guy if they would prefer a beautiful girlfriend or one which looks just average. Surprise, the same goes for women. Humans prefer beauty in their partners. It is instinctive and meant to help continue with the survival of the human species.

This newly published Research Study conducted by Christopher Watkins of Abertay University in Scotland helps to explain some of the extremely gorgeous women that I have dated in my life. The downside of dating a really great looking woman is that any other guys in the same room will be doing body scans of your girlfriend.

So how is that a physically gorgeous female super model would even go out with an average looking guy like me?

This new scientific study

Unfortunately, this does not apply to women. Displays of creativity by an average looking women, will not enhance her appeal to the eyes of a male. Us males are rather fixated on physical beauty. Your average looking female can have tons of “inner beauty” and in the end that is far more important. But males generally look at the outer packaging.

Click on this link to download a PDF copy of the published Research Study titled “Creating beauty: Creativity compensates for low physical attractiveness when individuals assess the attractiveness of social and romantic partners” by Christopher D. Watkins

Enough of Vince’s banter, I know that the readers here can’t wait to view this new Research Study, which is below. Please note that I am posting this new research with permission, but that does not mean that Christopher D. Watkins  or Abertay University in Scotland in any way endorse the Uniquely Toronto website or Vincent Banial.

Creating beauty: creativity compensates for low physical attractiveness when individuals assess the attractiveness of social and romantic partners

Christopher D. Watkins

Abstract

Although creativity is attractive in a potential mate, it is unclear (i) whether the effects of creativity on attractiveness generalize to other social contexts and (ii) whether creativity has equivalent effects on men’s and women’s attractiveness. As social knowledge of creativity may either enhance or ‘offset’ the appeal of social partners who differ in physical attractiveness, three repeated measures experiments were conducted to directly address these issues. Here, participants rated a series of face–text pairs for attractiveness on trials that differed in one of four combinations of facial attractiveness (attractive and less attractive) and creativity (creative and less creative), rating story-tellers in two experiments (short interpretations of an identical painting) and creative ideas in a further experiment (alternative uses for an everyday object). Regardless of the sex of the judge, creativity and facial attractiveness had independent effects on men’s overall attractiveness (initial experiment) and, in further experiments, more substantial effects on the attractiveness of men with less attractive faces than men with attractive faces (when using a different measure of creativity) and specific effects on the attractiveness of individuals with less attractive faces (when using different face stimuli). Collectively, across three experiments, these findings suggest that creativity may compensate for putative cues to lower biological ‘quality’ and that the benefits of creativity to social groups more generally enhance attraction to creative men (in two experiments) and creative men and women (one experiment). More broadly, the data suggest that species can integrate knowledge of cognitive intelligence with visual cues to biological ‘quality’ to facilitate mate and/or ally choice.

Continue reading

Researchers found that those who took acetaminophen showed a reduction in empathy.

A new Research Study out of The Ohio State University found that those who took acetaminophen showed a reduction in empathy. They weren’t as concerned about another person’s person’s hurt feelings. The Study was published on May 05 2016 in the journal “Social Congitive and Affective Neuroscience, which is one of the Oxford Journals.

Video is courtesy of the Fox Business YouTube channel

Acetaminophen is the main ingredient in the over the counter pain relief medication called Tylenol.

 

The authors of the study were:

Baldwin Way

Dominik Mischkowski

and Jennifer Crocker

 

Click on this line to visit the Oxford Journals site to view the Study Abstract
From Painkiller to Empathy Killer: Acetaminophen (Paracetamol) Reduces Empathy for Pain

 

Posted by: Vincent Banial
http://www.uniquelytoronto.com

Disclaimer: Any Trademarks mentioned in this post are owned by the respective Trademark owner. There could be unintentional errors or omissions in this post. Always refer to the official sites to confirm details and any ongoing changes or updates. This post is subject to change without notice.

Northwestern researchers have discovered that when the human egg is activated by a sperm enzyme, an explosion of zinc sparks erupt


Northwestern University researchers have discovered that when the human egg is activated by a sperm enzyme, an explosion of zinc sparks erupt

If the videos do not start automatically, then click on the two  links below. They are from the study published in Scientific Reports

http://www.nature.com/article-assets/npg/srep/2016/160426/srep24737/extref/srep24737-s1.avi

http://www.nature.com/article-assets/npg/srep/2016/160426/srep24737/extref/srep24737-s2.avi

Video is courtesy of GeoBeats News YouTube channel

Abstract

Egg activation refers to events required for transition of a gamete into an embryo, including establishment of the polyspermy block, completion of meiosis, entry into mitosis, selective recruitment and degradation of maternal mRNA, and pronuclear development. Here we show that zinc fluxes accompany human egg activation. We monitored calcium and zinc dynamics in individual human eggs using selective fluorophores following activation with calcium-ionomycin, ionomycin, or hPLCζ cRNA microinjection. These egg activation methods, as expected, induced rises in intracellular calcium levels and also triggered the coordinated release of zinc into the extracellular space in a prominent “zinc spark.” The ability of the gamete to mount a zinc spark response was meiotic-stage dependent. Moreover, chelation of intracellular zinc alone was sufficient to induce cell cycle resumption and transition of a meiotic cell into a mitotic one. Together, these results demonstrate critical functions for zinc dynamics and establish the zinc spark as an extracellular marker of early human development.

Click on this line to visit the Northwestern University website page where this research is discussed.

Click on this line to visit the Scientific Reports website to read the complete study titled:

The zinc spark is an inorganic signature of human egg activation

Please note that there is download link at the above linked to Scientific Reports site, which allows you to download the full study report.

Title:
The zinc spark is an inorganic signature of human egg activation

Authors: Francesca E. Duncan, Emily L. Que, Nan Zhang, Eve C. Feinberg, Thomas V. O’Halloran et al.

Publication: Scientific Reports

Publisher: Nature Publishing Group

Date: Apr 26, 2016

Copyright © 2016, Rights Managed by Nature Publishing Group

Creative Commons

The article for which you have requested permission has been distributed under a Creative Commons CC-BY license (please see the article itself for the license version number). You may reuse this material without obtaining permission from Nature Publishing Group, providing that the author and the original source of publication are fully acknowledged, as per the terms of the license.
For license terms, please see http://creativecommons.org/

 

Posted by: Vincent Banial
http://www.uniquelytoronto.com

Disclaimer: Any Trademarks mentioned in this post are owned by the respective Trademark owner.

If the Cancerous Tumor can be reached by thin optic fibers then this minimally invasive procedure could be an effective way to treat said Tumor

Getting any form of cancer can be life changing. The medical procedures used to eliminate the Cancer can also have life changing side effects.

Removing a Cancerous Prostate is one present way to deal with Colon Cancer.

There is a novel new procedure which has already been approved for use in Mexico. It may soon be approved for use in Europe.

The key part is that the procedure is minimally invasive. If the Cancerous Tumor can be reached by thin optic fibers then this procedure could be an effective way to treat said Tumor. The thin optic fiber is needed to direct the Laser light at the Tumor. “Laser light activation of an intravenous infusion of Tookad Soluble releases short-lived toxic oxygen and nitric oxide radicals that destroy the Cancer tumor’s blood vessels and thereby kill the tumorous cells”. The Tookad Soluble drug is eliminated from the body in less than 6 hours. Without the Laser Light activation the Tookad Soluble has no effect on other cells or organ. Ultra Sound is used to feed and direct the Optic Fibres into the patients body.

This new technology was developed by the Yeda Research and Development Company, of the Weizmann Institute in collaboration with Steba Biotech of Luxembourg. Steba Biotech received the license for Tookad Soluble from Yeda Research and Development Company.

Since this procedure can target Cancer Tumors where a Fibre Optic strand could reach the tumor, then the door may be open to treat many other forms of Cancer. More research and Clinical Studies are underway.

Click on this line to read much more detail about using Tookad Soluble activation via Laser Light to target Cancer Tumors.

Click on this line to visit the Times Of Israel news website to read their article on this procedure first developed by the Weizmann Institute.

 

 

Posted by: Vincent Banial
http://www.uniquelytoronto.com

Disclaimer: Any Trademarks mentioned in this post are owned by the respective Trademark owner. There could be unintentional errors or omissions in this post. Always refer to the official sites to confirm details and any ongoing changes or updates. This post is subject to change without notice.

Scanning ultrasound removes amyloid-β and restores memory in an Alzheimer’s disease mouse model

I used to post about Medical Research in the past. For example, our prior post about research done at Harvard regarding the association between Heart Disease and microbial Human Gut Bacteria had researchers from around the globe visiting this site. Hey life is not just about great looking Exotic Cars, great looking Women and great sounding Music. You should add Medical Research to “round out” that mix.

This post is about research being conducted in Australia, which shows great promise in the treatment of Alzheimers. Apparently some memory loss could be reversed, in mice so far, by using their protocol and Scanning UltraSound.

The study was conducted by : Gerhard Leinenga and Jürgen Götz. Corresponding author. E-mail: j.goetz@uq.edu.au

Their study was published in the peer reviewed journal: Science Translational Medicine 11 Mar 2015: Vol. 7, Issue 278

The article was titled: Research Article Alzheimer’s Disease
Scanning ultrasound removes amyloid-β and restores memory in an Alzheimer’s disease mouse model.

The following is the Abstract (posted for Educational purposes). A link is provided further down to access the complete text and a downloadable PDF.

Abstract

Amyloid-β (Aβ) peptide has been implicated in the pathogenesis of Alzheimer’s disease (AD). We present a nonpharmacological approach for removing Aβ and restoring memory function in a mouse model of AD in which Aβ is deposited in the brain. We used repeated scanning ultrasound (SUS) treatments of the mouse brain to remove Aβ, without the need for any additional therapeutic agent such as anti-Aβ antibody. Spinning disk confocal microscopy and high-resolution three-dimensional reconstruction revealed extensive internalization of Aβ into the lysosomes of activated microglia in mouse brains subjected to SUS, with no concomitant increase observed in the number of microglia. Plaque burden was reduced in SUS-treated AD mice compared to sham-treated animals, and cleared plaques were observed in 75% of SUS-treated mice. Treated AD mice also displayed improved performance on three memory tasks: the Y-maze, the novel object recognition test, and the active place avoidance task. Our findings suggest that repeated SUS is useful for removing Aβ in the mouse brain without causing overt damage, and should be explored further as a noninvasive method with therapeutic potential in AD.

Click on this line to view the complete text regarding the published results of this study.

Click on this line to view the entire article as a PDF or to Download a PDF copy of the Published material courtesy of the Science Translational Medicine site.

Click on this line to visit the official website of the Queensland Brain Institute at The University of Queensland Australia

Click on this line to visit the Clem Jones Centre for Ageing Dementia Research (CJCADR)

 

 

Posted by: Vincent Banial
http://www.uniquelytoronto.com

Disclaimer: Any Trademarks mentioned in this post are owned by the respective Trademark owner. There could be unintentional errors or omissions in this post. Always refer to the official sites to confirm details and any ongoing changes or updates. This post is subject to change without notice. The Study Abstract has been included in this post for Educational Purposes and so is covered by the Fair Use component of Copyright. Uniquely Toronto makes no claims regarding the copyright or other rights to the published material. Also complete links have been included to the Science Translational Medicine site.