A new study paper on Cornavirus (COVID-19) has been published on the medrXiv preprint journal, titled: “Patient-derived mutations impact pathogenicity of SARS-CoV-2”. The research was done at the Zhejiang University in Hangzhou, China. The researchers involved in the study were: Hangping Yao, Xiangyun Lu, Qiong Chen, Kaijin Xu, Yu Chen, Linfang Cheng, Fumin Liu, Zhigang Wu, Haibo Wu, Changzhong Jin, Min Zheng, Nanping Wu, Chao Jiang, Lanjuan Li
From the study: “In total, 33 mutations were identified (including 10 mutations observed in
120 mixed-populations), and 19 of these mutations were novel, according to the comparison
121 with 1111 genomic sequences available at GISAID on 3/24/2020.”
Since there are many mutations, creating a COVID-19 Vaccine will be that much more difficult. I suspect that there are many more mutations, say in Europe. As such, I am of the opinion that a viable Vaccine will not be developed.
One can Download a PDF of the research study paper on the website via the above mentioned link to the medrXiv website.
Posted by Vincent Banial
We all find ourselves in distressing times during this Coronavirus Crisis. Watching a comedy can give our bodies a break from the stress of it all. Laugh at the foolish antics on the TV or Computer screen, found in a great comedy can be helpful.
I started to binge out on Seinfeld episodes on Youtube.com. Watching Cramer’s antics put a smile back on my face, for at a short time. One day after watching a Seinfeld episode, another comedy starting playing. Youtube sometimes will show you things it thinks you would like. The show was called Hot in Cleveland. Yes a strange name for a comedy but then so was calling a show Seinfeld.
Hot In Cleveland reminded me of Seinfeld, so I started to watch more episodes. One episode featured a Seinfeld actor. The guy who played Neuman is a neighbour on Hot In Cleveland. I’m not a Neuman fan, but found that his character fit will in this show. So far he has appeared in one episode.
Hot In Cleveland stars Valerie Bertinelli, Jane Leeves, Wendie Malick, and Betty White. All the actresses are awesome. Betty White delivers some amazing one liners. The show will grow on you, as it has one me. If a good laugh will help improve you day of Social Distancing via Self Isolation, then I would highly suggest to visit Youtube.com and do a search on “Hot in Cleveland”. Watch a few episodes and it will grow on you, much like Seinfeld did..
Posted by Vincent Banial
A newly published research study by Xuhua Xai, a full Professor and researcher at the University of Ottawa (in Canada), points to Dogs and not Bats as causing the spread of Coronavirus COVID-19 to Humans.
The following is the Abstract from the study published in the Journal of Molecular Biology and Evolution:
Click on this link to visit the Journal of Molecular Biology and Evolution website to download a PDF of the Research Study titled:”Extreme genomic CpG deficiency in SARS-CoV-2 and evasion of host antiviral defense”.
Click on this link to visit the Journal of Molecular Biology and Evolution website.
Click on this link to visit the University of Ottawa page for Xuhua Xai.
Posted by Vincent Banial with permission from the Journal of Molecular Biology and Evolution and the author Xuhua Xai.
Researchers from Trinity College Dublin (Trinity) and Technological University Dublin (TU Dublin) have found that taking Vitamin D supplements may enhance resistance to respiratory infections such as Covid-19, or limit the severity of the illness for those that do become infected.
“Dr Declan Byrne (St. James’s Hospital and School of Medicine, Trinity) and Dr Daniel McCartney (TU Dublin), co-authors of the article published in the Irish Medical Journal on Friday, recommend that adults living in Ireland take 20-50 micrograms of vitamin D per day.”
Since there is no official treatment for Coronavirus COVID-19 infection, then preventative measures to build resistance to Respiratory Infection should be a consideration. It has been stated by researchers that humans in northern climate changed their skin colour so as to facilitate creating Vitamin D from sunlight. Our skin creates Vitamin D from exposure to UV Rays in sunlight. During winter months there may be a deficiency of Vitamin D in Humans living away from the equator where there is far less sunlight during Winter months.
During the Coronvirus Crisis with Social Distancing and Stay at Home orders, humans are exposed to precious little sunlight and hence may develop a Vitamin D deficiency making our bodies more prone to a Respiratory Infection. Since Vitamin D helps our bodies to build a resistance to Respiratory Infection, it may a consideration to take Vitamin D supplements daily.
Download a PDF of a Healthcare Professional summary of – Optimisation of Vitamin D Status for Enhanced Immuno-protection against Covid-19 – is available here.
Always discuss with your Doctor, if you wish to take Vitamin D Supplements. Your Doctor could test your blood to check the level of Vitamin D deficiency and could suggest and monitor the level of supplementation.
Posted by Vincent Banial
Professor Knut Wittkowski, for twenty years was the head of The Rockefeller University’s Department of Biostatistics, Epidemiology, and Research Design, discusses his professional views on social distancing and lockdown. He firmly believes that Schools should be opened to allow kids to become infected with COVID-19. This will allow Herd Immunity to develop, as Kids usually get mild if any symptoms.
One issue that Dr. Wittkowski does not touch on is the immense burden Coronavirus has placed on Hospitals. If you don’t have beds or ventilators for all patients then “SOCIAL DISTANCING” could reduce the burden on Hospitals. If the Healthcare system could handle the case load then this Doctor’s premise about leaving the situation alone, so as to reach “Herd Immunity” could apply. But the Healthcare system cannot even provide N95 facemasks to Frontline Doctors and Nurses. The other important factor is the lack of a SpecificTreatment for COVID-19. Infected people go to the Hospitals as their infections get worse. Without a specific treatment those infections grow worse and people end up dying.
Dr. Wittkowski discussed data which indicated that in China and South Korea, Herd Immunity may have already been reached before Social Distancing was started.
Video is courtesy of the Journeyman Pictures YouTube channel
00:36-Dr. Wittkowski explains his recommendations for how to best deal with COVID-19
01:36-Is self-isolation prolonging the duration of COVID-19?
02:33-Are policies of self-isolation or shelter-in-place a good idea?
03:46-The pandemic is over
04:27-Did China lie about its COVID-19 statistics?
05:03-The truth behind the statistics given by the government of the United States
07:52-Are we even reporting flu deaths anymore?
08:16-Why are hospitals being overwhelmed?
09:16-Shortage of medial supplies
10:19-Has social distancing prevented deaths from COVID-19?
11:55-Staying indoors can make the virus worse
16:02-Why social distancing won’t work for an airborne contagion
17:41-Do we need a vaccine for COVID-19?
18:31-Humans can grow immune to this virus
18:55-The data doesn’t say that COVID-19 is more contagious than the flu
22:43-Changes in reporting COVID-19 cases
25:33-What makes COVID-19 different than the Swine Flu
27:05-What are the possible health risks of sheltering in place?
27:43-The “Second Wave” of COVID-19
31:10-What should we do about sheltering in place?
32:24-Why we need to achieve natural herd immunity
34:17-Should we be testing everyone for COVID-19?
35:35-The real effects of COVID-19
38:53-The percentage of people who won’t have any symptoms
39:34-What should we do about COVID-19 at this point?
40:40-Is this really a pandemic?
40:50-What you should know
Click on this link to visit the medRXIV site to read a Research paper published by Dr. Wittkowski titled “The first three months of the COVID-19 epidemic: Epidemiological evidence for two separate strains of SARS-CoV-2 viruses spreading and implications for prevention strategies”
We are all going thru some stressful times. I have found that watching a comedy can relieve some of the stress. When life is no longer anything to laugh at, maybe the antics or Cramer and George from the Seinfeld series can make us laugh for at least a brief moment.
Long ago I learned that Google.com is our friend. Google also runs Youtube.com. I have found many full episodes of Seinfeld to be found on Youtube.com
You can find episodes by visiting www.youtube.com and doing a search for Seinfeld.
While doing a Google search on Seinfeld I came across the Canadian TV Channel “CTV” which is making available a couple of Seinfeld episodes and lots of other stuff.
Click on this link to visit the CTV webpage: https://www.ctv.ca/Seinfeld
Well I hope that watching a few episodes of Seinfeld will help take your mind off the worry during this time of Coronavirus crisis. Laughing at a great comedy can help relieve some stress…
Starting on April 06 some Beer Store locations in Ontario will now receive your empty Beer and Liquor bottles. I was surprised when I dropped by a local Beer Store and there was a sign saying that they no longer allow bottle returns at that location. This policy was due to the Coronavirus situation, as the Beer Store wanted to properly protect their Ontario employees.
At present only 71 Beer Store locations in Ontario will accept returns of empty bottles. They are listed below:
- Ajax – 1953 Ravenscroft Rd., L1T 0K4
- Barrie – 640 Yonge St., L4N 4E6
- Barrie – 71 Mapleview Dr., L4N 9H7
- Belleville – 113 Station St., K8N 4Z9
- Bowmanville – 195 King St. E., L1C 1C2
- Bracebridge – 505 Hwy. #118, P1L 1X1
- Bradford – 452 Holland St. W., L3Z 0G1
- Brampton – 198 Queen St. E., L6V 1B7
- Brampton – 11 Worthington Ave., L7A 2Y7
- Brantford – 50 Market St. S., N3S 2E5
- Brantford – 300 King George Rd., N3R 5L8
- Cambridge – 200 Franklin Blvd., N1R 5S2
- Chatham – 132 Richmond St., N7M 1N9
- East York – 380 Donlands Ave., M4J 3S3
- Etobicoke – 1530 Albion Rd., M9V 1B4
- Etobicoke – 3560 Lakeshore Blvd W., M8W 1N6
- Guelph – 710 Woolwich St., N1H 3Z1
- Hamilton – 150 Barton St. E., L7L 2W5
- Hamilton – 282 Parkdale Ave. N., L8H 5X7
- Hamilton – 1111 Barton St. E., L8H 2V2
- Hamilton – 1408 Upper James St., L9B 1K3
- Hanmer – 5085 Municipal Rd. #80, P3P 1R2
- Hanover – 576 11th St., N4N 1T5
- Kanata – 720 Eagleson Rd., K2M 2G9
- Kingston – 1090 Midland Ave., K7P 2X9
- Kitchener – 1255 Weber St. E., N2A 1C2
- Leamington – 255 Erie St. S., N8H 3C3
- Lindsay – 370 Kent St. W., K9V 6G8
- London – 1600 Dundas St., E. N5W 3C2
- London – 414 Wharncliffe Rd. S., N6J 2M5
- London – 1199 Oxford St. W., N6H 1V8
- Midland – 9350 Hwy #93, L4R 4K4
- Milton – 1071 Maple Ave., L9T 0A5
- Nepean – 1984 Baseline Rd., K2C 0C6
- North York – 81 Billy Bishop Way, M3K 2C8
- North York – 1718 Wilson Ave., M3L 1A6
- Oakville – 290 Hays Blvd., L6H 7P3
- Orillia – 275 Atherly Rd., L3V 1N7
- Orleans – 2276 Tenth Line Rd., K1E 3P6
- Oshawa – 200 Ritson Rd. N., L1G 1Z7
- Ottawa – 1860 Bank St., K1V 7Z8
- Ottawa – 7 Selkirk St., K1L 6N1
- Owen Sound – 965 10th St. W., N4K 5S2
- Pembroke – 311 Nelson St., K8A 3N5
- Peterborough – 570 Lansdowne St. W., K9J 6Z8
- Pickering – 1355 Kingston Rd., L1V 6K3
- Sarnia – 1107 Confederation, N7T 7H9
- Sault St. Marie – 250 Bruce St., P6B 1P1
- Sault St. Marie – 150 Churchill Blvd., P6A 3Z9
- Scarborough – 2360 Kennedy Rd., M1T 3H1
- Scarborough – 3130 Danforth Ave., M1L 1B2
- Scarborough – 2727 Eglinton Ave. E., M1K 2S2
- Scarborough – 871 Milner Ave., M1V 3A4
- St. Catherines – 99 Dieppe Rd., L2M 7N6
- St. Thomas – 1014 Talbot St., N5P 1G3
- Streetsville – 65 Queen St. N, L5N 1A4
- Sudbury – 42 Lorne St., P3C 4N8
- Sudbury – 1485 Lasalle Blvd., P3A 1Z9
- Sutton West – 20903 Dalton Rd., L0E 1R0
- (ON HOLD) Thunder Bay – 911 Fort William Rd., P7B 3A6
- (ON HOLD) Thunder Bay – 212 North Cumberland St., P7A 4N1
- Toronto – 500 Dupont St., M6G 1Y6
- Toronto – 227 Gerrard St. E., M5A 2E9
- Toronto – 2153 St. Clair Ave, M6N 1K5
- Vaughan – 9771 Jane St., L6A 3N9
- Waterloo – 70 Weber St. N, N2J 3G7
- Windsor – 2380 Walker Road, N8W 3P6
- Windsor – 790 Goyeau St., N9A 1H6
- Windsor – 8150 Tecumseh Blvd E., N8R 1A2
- Woodstock – 86 Beale St., N4S 6X4
Authorities like the CDC are not tracking Coronavirus Infections and Death rates based on whether the patient was Dark Skinned or White. In certain US States where such data is available, there seems to show alarming rates of Coronavirus Infection among Dark Skinned citizens.
Click on this link to view the New York Times article titled: “Black Americans face alarming rates of Coronavirus Infections in some states.”.
Click on this link to view the Chicago Tribune article titled: “Chicago’s coronavirus disparity: Black Chicagoans are dying at nearly six times the rate of white residents, data show“.
I suspect that part of the problem is the ability of US Citizens to get tested. Secretary Alex Azar, who leads the Department of Health and Human Services,had stated that a Doctor or Public-Health Official would need to approve and prescribe a Coronavirus Test. The CDC and the Food and Drug Administration initially had stringent rules that allowed only Americans who had traveled abroad to get tested. I suspect that many could not be tested until it was too late. There are unfortunately many US Citizens who cannot afford to see a Doctor to get a note asking that the patient be tested for Coronavirus.
I had read about a young male who was rejected at a testing center because allegedly he did not qualify. He later died. After his death, they tested him and he in fact was infected by Coronavirus. Sadly his Death, somehow qualified him to be tested.
Click on this link to visit the Independant News site to read their article titled: “Coronavirus: Teenage boy whose death was linked to COVID-19 turned away from urgent care for not having insurance“.
Click on this link to the Poynter.org article titled: “‘We have it totally under control.’ A timeline of President Donald Trump’s response to the coronavirus pandemic“.
Sadly the Coronavirus COVID-19 is not under control and citizens are dying.
Queen Elizabeth tried to comfort the United Kingdom, during this time of Coronavirus sweeping across Britain.
Click on the following link to view the Queens address and comments about it from Piers Morgan:
The symptoms shown by those infected with Coronavirus can vary widely. When searching the Internet, for symptom lists, you will find that often (but not always the Symptoms of a COVID-19 infection are similar to those found with respiratory illnesses including the flu and common cold. They include:
- Cough – usually a Dry Cough
- Sore throat
- Difficulty breathing
- Pneumonia in severe cases
Video is courtesy of the Science Insider YouTube channel.
Two unique symptoms which have recently been discovered, is the loss of Taste and Smell. One person described it to be like eating some Chocolate Ice cream and not being about to discern the Chocolate taste. The loss of one’s sense of smell can also point to a Coronavirus infection.
Stomach issues have also been mentioned by people who have suffered thru thru COVID-19 infection. One person mentioned pain in her stomach and wanting badly to burp but unable to do so.
Diarrhea has also been mentioned. Along with that is the idea of Fecal transmission of COVID-19. It is recommended to close the lid on a toilet before flushing. That would limit the spread of particles into the air in the washroom.
I might suggest that if at all possible, to limit the use of Public Washrooms. It is not just the idea of Fecal Transfer but an infected person would touch the Toilet’s Flush handle potentially leaving COVID-19 particles on the handle. If using a Public Washroom, please make sure to wash your hands using plenty of soap and hot water before leaving the Washroom. If possible dry your hands using paper towels. Why? It has been said the the hot air hand dryers may spread the COVID-19 virus particles into the air, which you then breathe.
Vitamin C is not a patented drug and so is low cost. The use of Vitamin C as a treatment protocol for Coronavirus infections is rarely mentioned in the main news media. When one gets sick, Vitamin C in your body is depleted.
There were initial reports out of China that Coronavirus patients were being given intravenous Vitamin C. Vitamin C is also know to help patients who get Sepsis, which can also be the result of acquiring Coronavirus.
A new report has been published by Medicine in Drug Discovery, a peer reviewed journal by Elsevier, which details treating Coronavirus Patients using intravenous Vitamin C.
Click on the report title link below to visit the Elsevier’s Medicine in Drug Discovery site to read the report:
The report is as follows courtesy of Elsevier and Medicine in Drug Discovery:
Author links open overlay panel Richard Z.Cheng
The COVID-19 (SARS-2-Cov) pandemic, first reported in Wuhan, China, is now spreading to many continents and countries, causing a severe public health burden. Currently, there is no vaccine or specific antiviral drug for this deadly disease. A quick, deployable and accessible, effective and safe treatment is urgently needed to save lives and curtail the spreading. Acute respiratory distress syndrome (ARDS) is a key factor of fatality. Significantly increased oxidative stress due to rapid release of free radicals and cytokines is the hallmark of ARDS which leads to cellular injury, organ failure and death. Early use of large dose antioxidants, such as vitamin C (VC) may become an effective treatment for these patients. Clinical studies also show that high-dose oral VC provides certain protection against viral infection. Neither intravenous nor oral administration of high-dose VC is associated with significant side effects. Therefore, this regimen should be included in the treatment of COVID-19 and used as a preventative measure for susceptible populations such as healthcare workers with higher exposure risks.
Coronaviruses and influenza are among the pandemic viruses that can cause lethal lung injuries and death from ARDS [, , ]. Viral infections could evoke “cytokine storm” that leads to lung capillary endothelial cell activation, neutrophil infiltration and increased oxidative stress (reactive oxygen and nitrogen species). ARDS, characteristic of severe hypoxemia, is usually accompanied by uncontrolled inflammation, oxidative injury and damage to the alveolar-capillary barrier . Increased oxidative stress is a major insult in pulmonary injury including acute lung injury (ALI) and ARDS, two clinical manifestations of acute respiratory failure with substantially high morbidity and mortality [5,6].
In a report of 29 patients with COVID-19 pneumonia, 27 (93%) showed increased hsCRP, a marker of inflammation and oxidative stress . Transcription factor, nuclear factor erythroid 2 (nfe2)-related factor 2 (nrf2), is a major regulator of antioxidant response element (ARE)-driven cytoprotective protein expression. Activation of Nrf2 signaling plays an essential role in preventing cells and tissues from injury induced by oxidative stress. VC, an important component of the cellular antioxidant system , is beneficial to critical care management . Cytokine storm is observed in both viral and bacterial infections  and results in increased oxidative stress via a common and non-specific pathway. Since the prevention and management of oxidative stress could be realized by large dose of antioxidants, this approach may be applicable to COVID-19 with intravenous high-dose VC based on the outcome of three previous clinical studies involving a total of 146 patients with sepsis .
Hemila and colleagues reported that various high-dose intravenous VC infusions (e.g., 200 mg/kg body weight/day, divided into 4 doses) shortened the intensive care unit (ICU) stay by 97.8% , accompanied by a significant reduction in the mortality rate . Such an experience was reproduced among patients ill with severe influenza [13,14]. Indeed, dietary antioxidants (VC and sulforaphane) were shown to decrease oxidative stress induced acute inflammatory lung injury in patients receiving mechanical ventilation . In addition, oral VC (e.g., 6 g daily) was able to reduce viral infection risk  or to improve symptoms .
High-dose intravenous VC has also been successfully used in the treatment of 50 moderate to severe COVID-19 patients in China. The doses used varied between 2 g and 10 g per day, given over a period of 8–10 h. Additional VC bolus may be required among patients in critical conditions. The oxygenation index was improving in real time and all the patients eventually cured and were discharged . In fact, high-dose VC has been clinically used for several decades and a recent NIH expert panel document states clearly that this regimen (1.5 g/kg body weight) is safe and without major adverse events .
Because the development of efficacious vaccines and antiviral drugs takes time, VC and other antioxidants are among currently available agents to mitigate COVID-19 associated ARDS. Given the fact that high-dose VC is safe, healthcare professionals should take a close look at this opportunity. Obviously, well-designed clinical studies are absolutely needed to develop standard protocols for bedside use.
Severe Coronavirus infections could result in the patient getting an acute respiratory Tract Infection requiring the use of a Ventilator to sustain life. Vitamin D could be an adjunctive treatment protocol to help patients with Coronavirus.
Vitamin D deficiency contributes directly to the acute respiratory distress syndrome (ARDS)
Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data
Low Vitamin D Status Occurs in 90% of Patients with ARDS and Is Associated with Longer Duration of Mechanical Ventilation
Please discuss the above with your Medical Doctor to see if the information may be of help. Self Medicating without the advice of your Medical Doctor(s) is not recommended.
Posted by Vincent Banial