Tagged: Can early and high intravenous dose of vitamin C prevent and treat coronavirus disease 2019 (COVID-19)
Queen Elizabeth tried to comfort her Nation
Queen Elizabeth tried to comfort the United Kingdom, during this time of Coronavirus sweeping across Britain.
Click on the following link to view the Queens address and comments about it from Piers Morgan:
Can early and high intravenous dose of vitamin C prevent and treat Coronavirus 2019 (COVID-19)?
Vitamin C is not a patented drug and so is low cost. The use of Vitamin C as a treatment protocol for Coronavirus infections is rarely mentioned in the main news media. When one gets sick, Vitamin C in your body is depleted.
There were initial reports out of China that Coronavirus patients were being given intravenous Vitamin C. Vitamin C is also know to help patients who get Sepsis, which can also be the result of acquiring Coronavirus.
Some New York Hospitals have also treated Coronavirus patients with intravenous Vitamin C.
A new report has been published by Medicine in Drug Discovery, a peer reviewed journal by Elsevier, which details treating Coronavirus Patients using intravenous Vitamin C.
Click on the report title link below to visit the Elsevier’s Medicine in Drug Discovery site to read the report:
Can early and high intravenous dose of vitamin C prevent and treat Coronavirus disease 2019 (COVID-19)?
The report is as follows courtesy of Elsevier and Medicine in Drug Discovery:
Author links open overlay panel Richard Z.Cheng
The COVID-19 (SARS-2-Cov) pandemic, first reported in Wuhan, China, is now spreading to many continents and countries, causing a severe public health burden. Currently, there is no vaccine or specific antiviral drug for this deadly disease. A quick, deployable and accessible, effective and safe treatment is urgently needed to save lives and curtail the spreading. Acute respiratory distress syndrome (ARDS) is a key factor of fatality. Significantly increased oxidative stress due to rapid release of free radicals and cytokines is the hallmark of ARDS which leads to cellular injury, organ failure and death. Early use of large dose antioxidants, such as vitamin C (VC) may become an effective treatment for these patients. Clinical studies also show that high-dose oral VC provides certain protection against viral infection. Neither intravenous nor oral administration of high-dose VC is associated with significant side effects. Therefore, this regimen should be included in the treatment of COVID-19 and used as a preventative measure for susceptible populations such as healthcare workers with higher exposure risks.
Coronaviruses and influenza are among the pandemic viruses that can cause lethal lung injuries and death from ARDS [, , ]. Viral infections could evoke “cytokine storm” that leads to lung capillary endothelial cell activation, neutrophil infiltration and increased oxidative stress (reactive oxygen and nitrogen species). ARDS, characteristic of severe hypoxemia, is usually accompanied by uncontrolled inflammation, oxidative injury and damage to the alveolar-capillary barrier . Increased oxidative stress is a major insult in pulmonary injury including acute lung injury (ALI) and ARDS, two clinical manifestations of acute respiratory failure with substantially high morbidity and mortality [5,6].
In a report of 29 patients with COVID-19 pneumonia, 27 (93%) showed increased hsCRP, a marker of inflammation and oxidative stress . Transcription factor, nuclear factor erythroid 2 (nfe2)-related factor 2 (nrf2), is a major regulator of antioxidant response element (ARE)-driven cytoprotective protein expression. Activation of Nrf2 signaling plays an essential role in preventing cells and tissues from injury induced by oxidative stress. VC, an important component of the cellular antioxidant system , is beneficial to critical care management . Cytokine storm is observed in both viral and bacterial infections  and results in increased oxidative stress via a common and non-specific pathway. Since the prevention and management of oxidative stress could be realized by large dose of antioxidants, this approach may be applicable to COVID-19 with intravenous high-dose VC based on the outcome of three previous clinical studies involving a total of 146 patients with sepsis .
Hemila and colleagues reported that various high-dose intravenous VC infusions (e.g., 200 mg/kg body weight/day, divided into 4 doses) shortened the intensive care unit (ICU) stay by 97.8% , accompanied by a significant reduction in the mortality rate . Such an experience was reproduced among patients ill with severe influenza [13,14]. Indeed, dietary antioxidants (VC and sulforaphane) were shown to decrease oxidative stress induced acute inflammatory lung injury in patients receiving mechanical ventilation . In addition, oral VC (e.g., 6 g daily) was able to reduce viral infection risk  or to improve symptoms .
High-dose intravenous VC has also been successfully used in the treatment of 50 moderate to severe COVID-19 patients in China. The doses used varied between 2 g and 10 g per day, given over a period of 8–10 h. Additional VC bolus may be required among patients in critical conditions. The oxygenation index was improving in real time and all the patients eventually cured and were discharged . In fact, high-dose VC has been clinically used for several decades and a recent NIH expert panel document states clearly that this regimen (1.5 g/kg body weight) is safe and without major adverse events .
Because the development of efficacious vaccines and antiviral drugs takes time, VC and other antioxidants are among currently available agents to mitigate COVID-19 associated ARDS. Given the fact that high-dose VC is safe, healthcare professionals should take a close look at this opportunity. Obviously, well-designed clinical studies are absolutely needed to develop standard protocols for bedside use.
D. Wang, B. Hu, C. Hu, F. Zhu, X. Liu, J. Zhang, et al.Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, ChinaJAMA, 323 (2020), pp. 1061-1069
N. Chen, M. Zhou, X. Dong, J. Qu, F. Gong, Y. Han, et al.Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive studyLancet, 395 (2020), pp. 507-513
A.A. Fowler III, C. Kim, L. Lepler, R. Malhotra, O. Debesa, R. Natarajan, et al.Intravenous vitamin C as adjunctive therapy for enterovirus/rhinovirus induced acute respiratory distress syndromeWorld J Crit Care Med, 6 (2017), pp. 85-90
L. Meng, X. Zhao, H. ZhangHIPK1 interference attenuates inflammation and oxidative stress of acute lung injury via autophagyMed Sci Monit, 25 (2019), pp. 827-835
X. Yan, X. Fu, Y. Jia, X. Ma, J. Tao, T. Yang, et al.Nrf2/Keap1/ARE signaling mediated an antioxidative protection of human placental mesenchymal stem cells of fetal origin in alveolar epithelial cellsOxid Med Cell Longev, 2019 (2019), p. 2654910
L. HeckerMechanisms and consequences of oxidative stress in lung disease: therapeutic implications for an aging populaceAm J Physiol Lung Cell Mol Physiol, 314 (2018), pp. L642-L653
L. Chen, H.G. Liu, W. Liu, J. Liu, K. Liu, J. Shang, et al.Analysis of clinical features of 29 patients with 2019 novel coronavirus pneumoniaZhonghua Jie He He Hu Xi Za Zhi, 43 (2020), Article E005
Q. Liu, Y. Gao, X. CiRole of Nrf2 and its activators in respiratory diseasesOxid Med Cell Longev, 2019 (2019), p. 7090534
C.S. Nabzdyk, E.A. BittnerVitamin C in the critically ill — indications and controversiesWorld J Crit Care Med, 7 (2018), pp. 52-61
J. LiEvidence is stronger than you think: a meta-analysis of vitamin C use in patients with sepsisCrit Care, 22 (2018), p. 258
H. Hemilä, E. ChalkerVitamin C can shorten the length of stay in the ICU: a meta-analysisNutrients, 11 (2019), p. 708
P.E. Marik, V. Khangoora, R. Rivera, M.H. Hooper, J. CatravasHydrocortisone, vitamin C, and thiamine for the treatment of severe sepsis and septic shock: a retrospective before-after studyChest, 151 (2017), pp. 1229-1238
- High dose vitamin C and influenza: a case report. ISOM, cited on Feb 9 2020 (https://isom.ca/article/high-dose-vitamin-c-influenza-case-report/?from=groupmessage&isappinstalled=0).
- Levy T. Primal Panacea. MedFox Publishing; 350 p. (Kindle Edition).
V. Patel, K. Dial, J. Wu, A.G. Gauthier, W. Wu, M. Lin, et al.Dietary antioxidants significantly attenuate hyperoxia-induced acute inflammatory lung injury by enhancing macrophage function via reducing the accumulation of airway HMGB1Int J Mol Sci, 21 (2020), p. 977
T.K. Kim, H.R. Lim, J.S. ByunVitamin C supplementation reduces the odds of developing a common cold in Republic of Korea Army recruits: randomised controlled trialBMJ Mil Health (2020), 10.1136/bmjmilitary-2019-001384
H.C. Gorton, K. JarvisThe effectiveness of vitamin C in preventing and relieving the symptoms of virus-induced respiratory infectionsJ Manipulative Physiol Ther, 22 (1999), pp. 530-533
Shanghai Expert Panel, cited on Mar 23
- High-dose vitamin C (PDQ®)–Health professional version. National Cancer Institute, cited on Feb 9 2020 (https://www.cancer.gov/about-cancer/treatment/cam/hp/vitamin-c-pdq).