Tagged: TMAO predictor of Cadriovascular Disease

Intestinal microbiota metabolism producing Trimethylamine-N-Oxide (TMAO), may be a contributing factor in developing Cardiovascular Disease in Humans. Very important study just published in Nature Medicine.

Geschätzte Prävalenz von Herz-Kreislauferkrank...

Geschätzte Prävalenz von Herz-Kreislauferkrankungen in den USA estimated prevalence of cardiovascular disease in the U.S. (Photo credit: Wikipedia)

On April 07 2013 a new and extremely important study was published by the peer-reviewed journal Nature Medicine.

This new study clearly demonstrated that the metabolism by Intestinal Microbiota of Dietary L-Carnitine, a Trimethylamine abundant in red meat, produced Trimethylamine-N-Oxide (TMAO) and accelerated the development of  Atherosclerosis in mice. This acceleration of Atherosclerosis did not occur, when the test group of mice were concurrently given antibiotics to suppress the population of Intestinal Microbiota.

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